Cervical Papillomaviruses Segregate Within Morphologically Distinct Precancerous Lesions

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1985 Jun 1

PMID 2987521

Citations 39

Authors

C P Crum

M Mitao

R U LEVINE

S Silverstein

Affiliations

Soon will be listed here.

Abstract

We combined molecular hybridization and histological analysis of 58 biopsy samples from the uterine cervix to correlate the presence of certain strains of human papillomaviruses (HPVs) with specific pathological changes. HPV sequences were frequently detected (85%) in biopsies that contained a broad spectrum of precancerous changes. The presence of HPV 16 correlated strongly with precancers that exhibited morphological aberrations commonly found in invasive carcinomas and precancers that have a high risk of progression. This association underscores the potential importance of HPV type 16 in the genesis of genital cancers and emphasizes the value of histological analysis for detecting potentially oncogenic HPVs.

Citing Articles

Protocol of Breast Cancer Prevention Model with Addition of Breast Ultrasound to Routine Gynecological Visits as a Chance for an Early Diagnosis and Treatment in 25 to 49-Year-Old Polish Females.

Sniadecki M, Jaworek P, Chmielewska Z, Poniewierza P, Stasiak M, Danielkiewicz M Diagnostics (Basel). 2023; 13(2).

PMID: 36673037 PMC: 9857976. DOI: 10.3390/diagnostics13020227.

Pathology: human papillomavirus infection and cervical neoplasia.

Winkler B, Palefsky J West J Med. 1986; 145(3):377-8.

PMID: 18750081 PMC: 1306942.

Coinfection of human foreskin fragments with multiple human papillomavirus types (HPV-11, -40, and -LVX82/MM7) produces regionally separate HPV infections within the same athymic mouse xenograft.

Christensen N, Koltun W, Cladel N, Budgeon L, Reed C, KREIDER J J Virol. 1997; 71(10):7337-44.

PMID: 9311811 PMC: 192078. DOI: 10.1128/JVI.71.10.7337-7344.1997.

Detection of human papillomavirus infection in squamous tumours of the conjunctiva and lacrimal sac by immunohistochemistry, in situ hybridisation, and polymerase chain reaction.

Nakamura Y, Mashima Y, Kameyama K, Mukai M, Oguchi Y Br J Ophthalmol. 1997; 81(4):308-13.

PMID: 9215061 PMC: 1722165. DOI: 10.1136/bjo.81.4.308.

Definition of human papillomavirus type 16 DNA levels in low and high grade cervical lesions by a simple polymerase chain reaction technique.

Terry G, Ho L, Jenkins D, Hills M, Singer A, Mansell B Arch Virol. 1993; 128(1-2):123-33.

PMID: 8380319 DOI: 10.1007/BF01309793.

References

Denhardt D . A membrane-filter technique for the detection of complementary DNA. Biochem Biophys Res Commun. 1966; 23(5):641-6. DOI: 10.1016/0006-291x(66)90447-5. View

Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H . A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J. 1984; 3(5):1151-7. PMC: 557488. DOI: 10.1002/j.1460-2075.1984.tb01944.x. View

Richart R . Cervical intraepithelial neoplasia. Pathol Annu. 1973; 8:301-28. View

Maniatis T, Jeffrey A, Kleid D . Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A. 1975; 72(3):1184-8. PMC: 432491. DOI: 10.1073/pnas.72.3.1184. View

Southern E . Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975; 98(3):503-17. DOI: 10.1016/s0022-2836(75)80083-0. View

Wahl G, Stern M, Stark G . Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A. 1979; 76(8):3683-7. PMC: 383897. DOI: 10.1073/pnas.76.8.3683. View

Birnboim H, DOLY J . A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 1979; 7(6):1513-23. PMC: 342324. DOI: 10.1093/nar/7.6.1513. View

Breitburd F, Favre M, Zoorob R, Fortin D, Orth G . Detection and characterization of viral genomes and search for tumoral antigens in two hamster cell lines derived from tumors induced by bovine papillomavirus type 1. Int J Cancer. 1981; 27(5):693-702. DOI: 10.1002/ijc.2910270517. View

Gissmann L, deVilliers E, zur Hausen H . Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int J Cancer. 1982; 29(2):143-6. DOI: 10.1002/ijc.2910290205. View

10.

WETTSTEIN F, Stevens J . Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some. Proc Natl Acad Sci U S A. 1982; 79(3):790-4. PMC: 345838. DOI: 10.1073/pnas.79.3.790. View

11.

Ferenczy A, Braun L, Shah K . Human papillomavirus (HPV) in condylomatous lesions of cervix. Am J Surg Pathol. 1981; 5(7):661-70. DOI: 10.1097/00000478-198110000-00008. View

12.

Ostrow R, Bender M, Niimura M, Seki T, Kawashima M, PASS F . Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis. Proc Natl Acad Sci U S A. 1982; 79(5):1634-8. PMC: 346030. DOI: 10.1073/pnas.79.5.1634. View

13.

Crum C, Fu Y, LEVINE R, Richart R, Townsend D, Fenoglio C . Intraepithelial squamous lesions of the vulva: biologic and histologic criteria for the distinction of condylomas from vulvar intraepithelial neoplasia. Am J Obstet Gynecol. 1982; 144(1):77-83. DOI: 10.1016/0002-9378(82)90398-2. View

14.

Gissmann L, Wolnik L, Ikenberg H, Koldovsky U, Schnurch H, zur Hausen H . Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci U S A. 1983; 80(2):560-3. PMC: 393419. DOI: 10.1073/pnas.80.2.560. View

15.

Durst M, Gissmann L, Ikenberg H, zur Hausen H . A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci U S A. 1983; 80(12):3812-5. PMC: 394142. DOI: 10.1073/pnas.80.12.3812. View

16.

Winkler B, Crum C, Fujii T, Ferenczy A, Boon M, Braun L . Koilocytotic lesions of the cervix. The relationship of mitotic abnormalities to the presence of papillomavirus antigens and nuclear DNA content. Cancer. 1984; 53(5):1081-7. DOI: 10.1002/1097-0142(19840301)53:5<1081::aid-cncr2820530511>3.0.co;2-l. View

17.

Crum C, Ikenberg H, Richart R, Gissman L . Human papillomavirus type 16 and early cervical neoplasia. N Engl J Med. 1984; 310(14):880-3. DOI: 10.1056/NEJM198404053101403. View

18.

KIRKLAND J, Stanley M, Cellier K . Comparative study of histologic and chromosomal abnormalities in cervical neoplasia. Cancer. 1967; 20(11):1934-52. DOI: 10.1002/1097-0142(196711)20:11<1934::aid-cncr2820201122>3.0.co;2-4. View