Evidence That Bisphenol A (BPA) Can Be Accurately Measured Without Contamination in Human Serum and Urine, and That BPA Causes Numerous Hazards from Multiple Routes of Exposure

Overview

Journal Mol Cell Endocrinol

Specialties Cell Biology
Endocrinology
Molecular Biology

Date 2014 Oct 12

PMID 25304273

Citations 55

Authors

Frederick S Vom Saal

Wade V Welshons

Affiliations

Soon will be listed here.

Abstract

There is extensive evidence that bisphenol A (BPA) is related to a wide range of adverse health effects based on both human and experimental animal studies. However, a number of regulatory agencies have ignored all hazard findings. Reports of high levels of unconjugated (bioactive) serum BPA in dozens of human biomonitoring studies have also been rejected based on the prediction that the findings are due to assay contamination and that virtually all ingested BPA is rapidly converted to inactive metabolites. NIH and industry-sponsored round robin studies have demonstrated that serum BPA can be accurately assayed without contamination, while the FDA lab has acknowledged uncontrolled assay contamination. In reviewing the published BPA biomonitoring data, we find that assay contamination is, in fact, well controlled in most labs, and cannot be used as the basis for discounting evidence that significant and virtually continuous exposure to BPA must be occurring from multiple sources.

Citing Articles

Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu.

Buoso E, Masi M, Limosani R, Oliviero C, Saeed S, Iulini M J Xenobiot. 2025; 15(1.

PMID: 39846545 PMC: 11755641. DOI: 10.3390/jox15010013.

Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring.

Kaimal A, Hooversmith J, Al Mansi M, Cherry A, Garrity J, Holmes P Front Endocrinol (Lausanne). 2025; 15():1479838.

PMID: 39839474 PMC: 11747983. DOI: 10.3389/fendo.2024.1479838.

The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).

Vom Saal F, Antoniou M, Belcher S, Bergman A, Bhandari R, Birnbaum L Environ Health Perspect. 2024; 132(4):45001.

PMID: 38592230 PMC: 11003459. DOI: 10.1289/EHP13812.

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies.

Dalamaga M, Kounatidis D, Tsilingiris D, Vallianou N, Karampela I, Psallida S Int J Mol Sci. 2024; 25(1).

PMID: 38203845 PMC: 10779569. DOI: 10.3390/ijms25010675.

Potential Effects of Bisphenol A on the Heart and Coronary Artery of Adult Male Rats and the Possible Role of L-Carnitine.

Badawy M, Elsherbiny M, Elshopakey G, Elsayyad A, El-Kattan M, Hamama M J Toxicol. 2023; 2022:7760594.

PMID: 36601412 PMC: 9807306. DOI: 10.1155/2022/7760594.

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