Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature

Overview

Journal J Oncol

Specialty Oncology

Date 2018 Jun 1

PMID 29849629

Citations 19

Authors

Gergely Varga

Gabor Mikala

Laszlo Gopcsa

Zoltan Csukly

Sarolta Kollai

Gyorgy Balazs

Timar Botond

Nikolett Wohner

Laura Horvath

Gergely Szombath

Peter Farkas

Tamas Masszi

Affiliations

Soon will be listed here.

Abstract

Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk features initially; two had plasma cell leukemia. Repeated genetic tests showed clonal evolution in 3 cases. Treatments varied according to the era, and efficacy was poor as generally reported in the literature. Only one patient is currently alive, with 3-month follow-up, and the patient responded to daratumumab-based treatment. Recent case reports show promising effectivity of pomalidomide and marizomib.

Citing Articles

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Encephalitis associated with a monoclonal protein band present in blood, urine and cerebrospinal fluid.

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