Multiple Myeloma with Dural Mater Involvement

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2019 May 24

PMID 31118689

Citations 3

Authors

Su Liu

Xubin Li

Yueyang Li

Dongying Li

Yafei Wang

Chen Tian

Affiliations

Soon will be listed here.

Abstract

Multiple myeloma is an incurable clonal B-cell malignancy which may present with neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement such as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement, is uncommon. Dural involvement of myeloma without parenchymal or leptomeningeal disease is an even rarer occurrence; therefore there are no established treatment guidelines for CNS myelomatosis. Here we reported a refractory MM patient progressed to dura mater involvement after the induction therapy but showed good response to lenalidomide treatment.

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References

Roddie P, Collie D, Johnson P . Myelomatous involvement of the dura mater: a rare complication of multiple myeloma. J Clin Pathol. 2000; 53(5):398-9. PMC: 1731199. DOI: 10.1136/jcp.53.5.398. View

Maghfoor I, Perry M . Malignancy: Meningeal Myeloma: A Case Report and Review of Literature. Hematology. 2001; 5(1):47-52. DOI: 10.1080/10245332.2000.11746487. View

Cerase A, Tarantino A, Gozzetti A, Muccio C, Gennari P, Monti L . Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay. Neuroradiology. 2008; 50(8):665-74. DOI: 10.1007/s00234-008-0390-x. View

Creach K, Foote R, Neben-Wittich M, Kyle R . Radiotherapy for extramedullary plasmacytoma of the head and neck. Int J Radiat Oncol Biol Phys. 2008; 73(3):789-94. DOI: 10.1016/j.ijrobp.2008.04.077. View

Mendez C, Hwang B, Destian S, Mazumder A, Jagannath S, Vesole D . Intracranial multifocal dural involvement in multiple myeloma: case report and review of the literature. Clin Lymphoma Myeloma Leuk. 2010; 10(3):220-3. DOI: 10.3816/CLML.2010.n.035. View

Gozzetti A, Cerase A, Lotti F, Rossi D, Palumbo A, Petrucci M . Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients. Cancer. 2011; 118(6):1574-84. DOI: 10.1002/cncr.26447. View

Mussetti A, Dalto S, Montefusco V . Effective treatment of pomalidomide in central nervous system myelomatosis. Leuk Lymphoma. 2012; 54(4):864-6. DOI: 10.3109/10428194.2012.718343. View

Lee D, Kalff A, Low M, Gangatharan S, Ho P, Bajel A . Central nervous system multiple myeloma--potential roles for intrathecal therapy and measurement of cerebrospinal fluid light chains. Br J Haematol. 2013; 162(3):371-5. DOI: 10.1111/bjh.12404. View

Jurczyszyn A, Grzasko N, Gozzetti A, Czepiel J, Cerase A, Hungria V . Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice. Am J Hematol. 2016; 91(6):575-80. PMC: 5502095. DOI: 10.1002/ajh.24351. View

10.

Kusano Y, Terui Y, Nishimura N, Yokoyama M, Ueda K, Hatake K . Myelomatous meningitis: a case report. Int J Hematol. 2016; 104(2):149-50. DOI: 10.1007/s12185-016-2024-0. View

11.

Wilberger A, Prayson R . Intracranial Involvement by Plasma Cell Neoplasms. Am J Clin Pathol. 2016; 146(2):156-62. DOI: 10.1093/ajcp/aqw058. View

12.

Wang A, Bogusz A . Extreme Amyloid Depositions in the Calvarium and Dura Associated With Plasma Cell Myeloma. Int J Surg Pathol. 2016; 25(2):163-164. DOI: 10.1177/1066896916668991. View

13.

Siegel R, Miller K, Jemal A . Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1):7-30. DOI: 10.3322/caac.21387. View

14.

Badros A, Singh Z, Dhakal B, Kwok Y, MacLaren A, Richardson P . Marizomib for central nervous system-multiple myeloma. Br J Haematol. 2017; 177(2):221-225. DOI: 10.1111/bjh.14498. View

15.

Nahi H, Genell A, Walinder G, Uttervall K, Juliusson G, Karin F . Incidence, characteristics, and outcome of solitary plasmacytoma and plasma cell leukemia. Population-based data from the Swedish Myeloma Register. Eur J Haematol. 2017; 99(3):216-222. DOI: 10.1111/ejh.12907. View

16.

Kaito S, Muto H, Takebayashi S, Otsubo Y, Miyawaki S, Ohashi K . Extradural plasmacytoma with central nervous system involvement in newly diagnosed multiple myeloma. Int J Hematol. 2017; 106(4):455-456. DOI: 10.1007/s12185-017-2277-2. View

17.

Gascon N, Perez-Montero H, Guardado S, DAmbrosi R, Cabeza M, Perez-Regadera J . Dural Plasmacytoma with Meningeal Myelomatosis in a Patient with Multiple Myeloma. Case Rep Hematol. 2018; 2018:6730567. PMC: 5831945. DOI: 10.1155/2018/6730567. View

18.

Varga G, Mikala G, Gopcsa L, Csukly Z, Kollai S, Balazs G . Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature. J Oncol. 2018; 2018:3970169. PMC: 5937370. DOI: 10.1155/2018/3970169. View