A Blueprint for Human Whole-cell Modeling

Overview

Journal Curr Opin Syst Biol

Date 2018 May 29

PMID 29806041

Citations 38

Authors

Balazs Szigeti

Yosef D Roth

John A P Sekar

Arthur P Goldberg

Saahith C Pochiraju

Jonathan R Karr

Affiliations

Soon will be listed here.

Abstract

Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the , to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.

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