Role of Glutathione Peroxidase 1 in Glucose and Lipid Metabolism-related Diseases

Overview

Journal Free Radic Biol Med

Specialties Biochemistry
Biology
General Medicine

Date 2018 May 26

PMID 29800654

Citations 43

Authors

Jia-Qiang Huang

Ji-Chang Zhou

Yuan-Yuan Wu

Fa-Zheng Ren

Xin Gen Lei

Affiliations

Soon will be listed here.

Abstract

Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. While past research explored regulations of gene expression and biochemical function of this selenoperoxidase, GPX1 has recently been implicated in the onset and development of chronic diseases. Clinical data have shown associations of human GPX1 gene variants with elevated risks of diabetes. Knockout and overexpression of Gpx1 in mice may induce types 1 and 2 diabetes-like phenotypes, respectively. This review assembles the latest advances in this new field of selenium biology, and attempts to postulate signal and molecular mechanisms mediating the role of GPX1 in glucose and lipid metabolism-related diseases. Potential therapies by harnessing the beneficial effects of this ubiquitous redox-modulating enzyme are briefly discussed.

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