Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Mar 11

PMID 36902173

Authors

Iuliia Azarova

Alexey Polonikov

Elena Klyosova

Affiliations

Soon will be listed here.

Abstract

Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review summarizes the current state of the art advances in understanding the role of abnormal redox homeostasis in the molecular mechanisms of T2D and provides comprehensive information on the characteristics and biological functions of antioxidant and oxidative enzymes, as well as discusses genetic studies conducted so far in order to investigate the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis.

Citing Articles

Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer.

Hu D, Li Y, Li R, Wang M, Zhou K, He C Acta Pharm Sin B. 2025; 14(12):5106-5131.

PMID: 39807318 PMC: 11725102. DOI: 10.1016/j.apsb.2024.10.015.

Effect of Arsenic Exposure on AS3MT Protein Levels in Serum of Type 2 Diabetic Patients Compared to Non-diabetics.

Shokat S, Iqbal R, Ali M, Yaqub A, Aslam S, Riaz S Biol Trace Elem Res. 2024; .

PMID: 39699707 DOI: 10.1007/s12011-024-04448-2.

NADPH oxidase 5 is a novel susceptibility gene for type 2 diabetes mellitus.

Azarova I, Klyosova E, Azarova V, Polonikov A Arch Endocrinol Metab. 2024; 68:e230527.

PMID: 39529984 PMC: 11554360. DOI: 10.20945/2359-4292-2023-0527.

Redox Homeostasis and Molecular Biomarkers in Precision Therapy for Cardiovascular Diseases.

Dragoi C, Diaconu C, Nicolae A, Dumitrescu I Antioxidants (Basel). 2024; 13(10).

PMID: 39456418 PMC: 11504313. DOI: 10.3390/antiox13101163.

Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study.

Naja K, Anwardeen N, Bashraheel S, Elrayess M J Pharm Pharm Sci. 2024; 27:13305.

PMID: 39355646 PMC: 11442225. DOI: 10.3389/jpps.2024.13305.

References

Bogaards J, Venekamp J, van Bladeren P . Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1. Chem Res Toxicol. 1997; 10(3):310-7. DOI: 10.1021/tx9601770. View

Priscakova P, Minarik G, Repiska V . Candidate gene studies of diabetic retinopathy in human. Mol Biol Rep. 2016; 43(12):1327-1345. PMC: 5102952. DOI: 10.1007/s11033-016-4075-y. View

Kim M, Kim D, Lee J . FoxO Transcription Factors: Applicability as a Novel Immune Cell Regulators and Therapeutic Targets in Oxidative Stress-Related Diseases. Int J Mol Sci. 2022; 23(19). PMC: 9569616. DOI: 10.3390/ijms231911877. View

Awasthi Y, Sharma R, Cheng J, Yang Y, Sharma A, Singhal S . Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol Aspects Med. 2003; 24(4-5):219-30. DOI: 10.1016/s0098-2997(03)00017-7. View

Dai N, Zhao L, Wrighting D, Kramer D, Majithia A, Wang Y . IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015; 21(4):609-21. PMC: 4663978. DOI: 10.1016/j.cmet.2015.03.006. View

Williams A, Kang L, Wasserman D . The extracellular matrix and insulin resistance. Trends Endocrinol Metab. 2015; 26(7):357-66. PMC: 4490038. DOI: 10.1016/j.tem.2015.05.006. View

Pizzorno J . Glutathione!. Integr Med (Encinitas). 2016; 13(1):8-12. PMC: 4684116. View

Gimenez M, Schickling B, Lopes L, Miller Jr F . Nox1 in cardiovascular diseases: regulation and pathophysiology. Clin Sci (Lond). 2015; 130(3):151-65. DOI: 10.1042/CS20150404. View

Watanabe R . Physiologic Interpretation of GWAS Signals for Type 2 Diabetes. Methods Mol Biol. 2018; 1706:323-351. DOI: 10.1007/978-1-4939-7471-9_18. View

10.

Cirillo E, Kutmon M, Gonzalez Hernandez M, Hooimeijer T, Adriaens M, Eijssen L . From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results. PLoS One. 2018; 13(4):e0193515. PMC: 5884486. DOI: 10.1371/journal.pone.0193515. View

11.

Spijkerman A, van der A D, Nilsson P, Ardanaz E, Gavrila D, Agudo A . Smoking and long-term risk of type 2 diabetes: the EPIC-InterAct study in European populations. Diabetes Care. 2014; 37(12):3164-71. DOI: 10.2337/dc14-1020. View

12.

Huang S, Wu F, Luo M, Ma L, Gao K, Li J . The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. PLoS One. 2013; 8(2):e56722. PMC: 3578943. DOI: 10.1371/journal.pone.0056722. View

13.

Bergman R, Iyer M . Indirect Regulation of Endogenous Glucose Production by Insulin: The Single Gateway Hypothesis Revisited. Diabetes. 2017; 66(7):1742-1747. DOI: 10.2337/db16-1320. View

14.

Nolan C, Ruderman N, Kahn S, Pedersen O, Prentki M . Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes. Diabetes. 2015; 64(3):673-86. PMC: 4338588. DOI: 10.2337/db14-0694. View

15.

Diergaarde B, Brand R, Lamb J, Cheong S, Stello K, Barmada M . Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis. Pancreatology. 2010; 10(2-3):194-200. PMC: 2899150. DOI: 10.1159/000236023. View

16.

Zhao W, Rasheed A, Tikkanen E, Lee J, Butterworth A, Howson J . Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nat Genet. 2017; 49(10):1450-1457. PMC: 5844224. DOI: 10.1038/ng.3943. View

17.

Jyoti A, Singh A, Dubey M, Kumar S, Saluja R, Keshari R . Interaction of inducible nitric oxide synthase with rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes: implication in microbial killing. Antioxid Redox Signal. 2013; 20(3):417-31. DOI: 10.1089/ars.2012.4970. View

18.

Schormann N, Hayden K, Lee P, Banerjee S, Chattopadhyay D . An overview of structure, function, and regulation of pyruvate kinases. Protein Sci. 2019; 28(10):1771-1784. PMC: 6739817. DOI: 10.1002/pro.3691. View

19.

Sies H, Jones D . Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020; 21(7):363-383. DOI: 10.1038/s41580-020-0230-3. View

20.

Moreno-Gonzalez I, Edwards Iii G, Salvadores N, Shahnawaz M, Diaz-Espinoza R, Soto C . Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding. Mol Psychiatry. 2017; 22(9):1327-1334. PMC: 5495631. DOI: 10.1038/mp.2016.230. View