The Development and Impact of Heterotopic Ossification in Burns: a Review of Four Decades of Research

Overview

Journal Scars Burn Heal

Publisher Sage Publications

Date 2018 May 26

PMID 29799559

Citations 12

Authors

Rachel Kornhaber

Nichola Foster

Dale Edgar

Denis Visentin

Elad Ofir

Josef Haik

Moti Harats

Affiliations

Soon will be listed here.

Abstract

Introduction: Heterotopic ossification (HO) is the formation of lamellar bone within connective and other tissue where bone should not form and is a rare complication after burn injury. However, it leads to severe pain and distress, marked reduction in joint range of motion (ROM), impaired function and increased hospital length of stay. The pathophysiology, incidence and risk factors of HO remain poorly understood in burns and other traumas and the management, controversial. The aim of this comprehensive review, therefore, was to synthesise the available evidence on the development and treatment of HO after acute burn injury.

Methods: The review was based on a systematic search of five electronic databases PubMed, EMBASE, CINAHL, LILACS and Scopus.

Results: Synthesis and analysis of the data highlighted that, despite the passage of time, little translatable evidence is available to guide any prevention, screening, diagnostic or pharmacological or physical management protocols.

Discussion: Causes of HO remain confounded, therefore prevention is difficult. Although spontaneous resolution is possible, surgical resection remains the recommended treatment when ROM and activities of daily living are severely affected.

Conclusion: The findings from this review indicate that multicentre data pooling is needed to understand the optimum pathway to prevention, identification and treatment of HO in acute burn patients.

Citing Articles

A scoping review on active vs. passive range of motion approaches to treat heterotopic ossification at the elbow.

Siegel P, Smith S, Stark E, Burns C, Dionne T Front Rehabil Sci. 2024; 5:1327417.

PMID: 38903480 PMC: 11188409. DOI: 10.3389/fresc.2024.1327417.

Case report: Focal heterotopic ossification in paravertebral muscles as a cause of neurogenic lameness in a dog.

Hajek I, Rosati M, Matiasek K, Babinsky M, Caine A, Palus V Front Vet Sci. 2024; 11:1335175.

PMID: 38846781 PMC: 11155668. DOI: 10.3389/fvets.2024.1335175.

Musculoskeletal Issues in Pediatric Burn Patients.

Phillips W Semin Plast Surg. 2024; 38(2):154-156.

PMID: 38746697 PMC: 11090656. DOI: 10.1055/s-0044-1782651.

Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification.

Juan C, Bancroft A, Choi J, Nunez J, Pagani C, Lin Y Biomolecules. 2024; 14(3).

PMID: 38540768 PMC: 10968060. DOI: 10.3390/biom14030349.

Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance.

Liu F, Zhao Y, Pei Y, Lian F, Lin H Cell Commun Signal. 2024; 22(1):159.

PMID: 38439078 PMC: 10910758. DOI: 10.1186/s12964-024-01533-w.

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