Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2018 May 26

PMID 29796621

Citations 2

Authors

Caitlin E Stallings

Buffy S Ellsworth

Affiliations

Soon will be listed here.

Abstract

The process by which the somatotrope lineage emerges in the developing pituitary is regulated by the activity of specific signaling and transcription factors expressed during development. We set out to understand the contribution of FOXO1 to that process by using a mouse model in which FOXO1 is prematurely expressed in the pituitary primordium. Expression of FOXO1 in the oral ectoderm as early as embryonic day (e)9.5 resulted in pituitary gland hypoplasia and reduced expression of anterior lobe hormone transcripts at e18.5. Of note, the relative numbers of somatotropes and thyrotropes were also decreased at e18.5. LHX3 and PITX2, markers of pituitary identity, were present in a reduced number of cells during the formation of the Rathke pouch. Thus, premature expression of FOXO1 may affect adoption of pituitary identity during differentiation. Our results demonstrate that the timing of FOXO1 activation affects its role in pituitary gland organogenesis and somatotrope differentiation.

Citing Articles

Overview of chromatin regulatory processes during surface ectodermal development and homeostasis.

Branch M, Weber M, Li M, Flora P, Ezhkova E Dev Biol. 2024; 515:30-45.

PMID: 38971398 PMC: 11317222. DOI: 10.1016/j.ydbio.2024.07.001.

FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth.

Stallings C, Kapali J, Evans B, McGee S, Ellsworth B Endocrinology. 2021; 163(2).

PMID: 34971379 PMC: 8782608. DOI: 10.1210/endocr/bqab263.

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