Direct and Indirect Requirements of Shh/Gli Signaling in Early Pituitary Development

Overview

Journal Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2010 Oct 12

PMID 20934421

Citations 33

Authors

Yiwei Wang

James F Martin

C Brian Bai

Affiliations

Soon will be listed here.

Abstract

Induction of early pituitary progenitors is achieved through combined activities of signals from adjacent embryonic tissues. Previous studies have identified a requirement for oral ectoderm derived Sonic Hedgehog (Shh) in specification and/or proliferation of early pituitary progenitors, however how different Gli genes mediate Shh signaling to control pituitary progenitor development has not yet been determined. Here we show that Gli2, which encodes a major Gli activator, is required for proliferation of specific groups of pituitary progenitors but not for initial dorsoventral patterning. We further show that the action of Gli2 occurs prior to the closure of Rathke' pouch. Lastly, we show that Shh/Gli2 signaling controls the diencephalic expression of Bone morphogenetic protein 4 (Bmp4) and Fibroblast growth factor 8 (Fgf8), two genes that are known to play critical roles in patterning and growth of Rathke's pouch. Our results therefore suggest both cell-autonomous and non-cell-autonomous requirements for Gli2 in regulation of pituitary progenitor specification, proliferation and differentiation.

Citing Articles

Variety of genetic defects in GnRH and hypothalamic-pituitary signaling and development in normosmic patients with IHH.

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The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development.

Lodge E, Barrell W, Liu K, Andoniadou C J Anat. 2023; 244(2):358-367.

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Bian Y, Hahn H, Uhmann A Front Endocrinol (Lausanne). 2023; 14:1219018.

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Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling.

Winningham A, Camper S Endocrinology. 2023; 164(3).

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Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells.

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