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Cancer Stem Cells of Hepatocellular Carcinoma

Overview
Journal Oncotarget
Specialty Oncology
Date 2018 May 26
PMID 29796190
Citations 14
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Abstract

Hepatocellular carcinoma is a malignant tumor arising from hepatocytes. The hepatocellular carcinoma is dictated by a subset of cells with stem cell-like features. These cells are apoptosis-resistant and have particular biomarkers, which serve as seeds in different stages of tumorigenesis including initiation, progression, metastasis, and relapse of hepatocellular carcinoma. Signaling pathways of cancer stem cells are novel targets for the radical intervention of hepatocellular carcinoma.

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References
1.
Donato M, Arosio E, Monti V, Fasani P, Prati D, Sangiovanni A . Proliferating cell nuclear antigen assessed by a computer-assisted image analysis system in patients with chronic viral hepatitis and cirrhosis. Dig Liver Dis. 2002; 34(3):197-203. DOI: 10.1016/s1590-8658(02)80193-1. View

2.
Castelli G, Pelosi E, Testa U . Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells. Cancers (Basel). 2017; 9(9). PMC: 5615342. DOI: 10.3390/cancers9090127. View

3.
Guo W, Liu S, Cheng Y, Lu L, Shi J, Xu G . ICAM-1-Related Noncoding RNA in Cancer Stem Cells Maintains ICAM-1 Expression in Hepatocellular Carcinoma. Clin Cancer Res. 2015; 22(8):2041-50. DOI: 10.1158/1078-0432.CCR-14-3106. View

4.
Williams G, Gebhardt R, Sirma H, Stenback F . Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine. Carcinogenesis. 1993; 14(10):2149-56. DOI: 10.1093/carcin/14.10.2149. View

5.
Fang C, Gong J, Zhang W . Function of oval cells in hepatocellular carcinoma in rats. World J Gastroenterol. 2004; 10(17):2482-7. PMC: 4572146. DOI: 10.3748/wjg.v10.i17.2482. View