Interpreting the Various Associations of MiRNA Polymorphisms with Susceptibilities of Cardiovascular Diseases: Current Evidence Based on a Systematic Review and Meta-analysis

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2018 May 26

PMID 29794746

Citations 3

Authors

Kaiyu Zhou

Peng Yue

Fan Ma

Hualin Yan

Yi Zhang

Chuan Wang

Dajian Qiu

Yimin Hua

Yifei Li

Affiliations

Soon will be listed here.

Abstract

Background: To interpret the various associations between miRNA polymorphisms and cardiovascular diseases (CVD).

Methods: Literature search has identified relevant studies up to June 2016. A meta-analysis was performed followed the guidelines from the Cochrane review group and the PRISMA statement. Studies were identified by searching the Cochrane Library, EMBASE, PUBMED and WHO clinical trials registry center. A meta-analysis has been done with a fixed/random-effect model using STATA 14.0, which also has been used to estimate the publication bias and meta-regression.

Results: The results from 11 case-control studies were included. The miR-146a G/C makes a contribution to the causing of CVD as recessive genetic model. And the miR-499 G/A raised the risks of cardiomyopathy, however it could still accelerate the procedure of CVD combined with myocardial infraction. At this point, we consider that it could deepen the adverse of outcomes from coronary artery disease (CAD), but it's hard to draw an association between miR-499 G/A and CAD. At last the miR-196a2 T/C demonstrated a contrary role between development problem and metabolic issues, which protects the development procedure and impairs the metabolism to cause different disease phenotypes.

Conclusion: Despite inter-study variability, the polymorphisms from miR-146a, miR-499 and miR-196a2 have impacts on cardiovascular disease. Each type of miRNA has individual role in either cardiac development or the origins of CVD.

Citing Articles

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miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression.

Benito-Vicente A, Uribe K, Rotllan N, Ramirez C, Jebari-Benslaiman S, Goedeke L Int J Mol Sci. 2020; 21(22).

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miR-196a2 (rs11614913) polymorphism is associated with coronary artery disease, but not with in-stent coronary restenosis.

Fragoso J, Ramirez-Bello J, Martinez-Rios M, Pena-Duque M, Posadas-Sanchez R, Delgadillo-Rodriguez H Inflamm Res. 2018; 68(3):215-221.

PMID: 30560371 DOI: 10.1007/s00011-018-1206-z.

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