Estrogen Receptor β Promotes Renal Cell Carcinoma Progression Via Regulating LncRNA HOTAIR-miR-138/200c/204/217 Associated CeRNA Network

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2018 May 24

PMID 29789714

Citations 65

Authors

Jie Ding

Chiuan-Ren Yeh

Yin Sun

Changyi Lin

Joshua Chou

Zhenyu Ou

Chawnshang Chang

Jun Qi

Shuyuan Yeh

Affiliations

Soon will be listed here.

Abstract

Recent studies indicated that the estrogen receptor beta (ERβ) could affect the progression of prostate and bladder tumors, however, its roles in the renal cell carcinoma (RCC), remain to be elucidated. Here, we provide clinical evidence that ERβ expression is correlated in a negative manner with the overall survival/disease-free survival in RCC patients. Mechanism dissection revealed that targeting ERβ with ERβ-shRNA and stimulating the transactivation of ERβ with 17β-estradiol or environmental endocrine disrupting chemicals, all resulted in altering the lncRNA HOTAIR expression. The ERβ-modulated HOTAIR is able to function via antagonizing several microRNAs, including miR-138, miR-200c, miR-204, or miR-217 to impact various oncogenes, including ADAM9, CCND2, EZH2, VEGFA, VIM, ZEB1, and ZEB2, to promote RCC proliferation and invasion. Together, the identification of the ERβ-HOTAIR axis may provide us new biomarkers and/or therapeutic targets to better suppress RCC progression in the future.

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References

Hobisch A, Culig Z, Radmayr C, Bartsch G, Klocker H, HITTMAIR A . Distant metastases from prostatic carcinoma express androgen receptor protein. Cancer Res. 1995; 55(14):3068-72. View

Hsu I, Chuang K, Slavin S, Da J, Lim W, Pang S . Suppression of ERβ signaling via ERβ knockout or antagonist protects against bladder cancer development. Carcinogenesis. 2013; 35(3):651-61. DOI: 10.1093/carcin/bgt348. View

Perkel J . Visiting "noncodarnia". Biotechniques. 2013; 54(6):301, 303-4. DOI: 10.2144/000114037. View

Yoon J, Abdelmohsen K, Gorospe M . Functional interactions among microRNAs and long noncoding RNAs. Semin Cell Dev Biol. 2014; 34:9-14. PMC: 4163095. DOI: 10.1016/j.semcdb.2014.05.015. View

Yang G, Lu X, Yuan L . LncRNA: a link between RNA and cancer. Biochim Biophys Acta. 2014; 1839(11):1097-109. DOI: 10.1016/j.bbagrm.2014.08.012. View

Wagener N, Macher-Goeppinger S, Pritsch M, Husing J, Hoppe-Seyler K, Schirmacher P . Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma. BMC Cancer. 2010; 10:524. PMC: 2958940. DOI: 10.1186/1471-2407-10-524. View

Finley D, Pantuck A, Belldegrun A . Tumor biology and prognostic factors in renal cell carcinoma. Oncologist. 2011; 16 Suppl 2:4-13. PMC: 3868202. DOI: 10.1634/theoncologist.2011-S2-04. View

Kartha R, Subramanian S . Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation. Front Genet. 2014; 5:8. PMC: 3906566. DOI: 10.3389/fgene.2014.00008. View

Niu Y, Altuwaijri S, Yeh S, Lai K, Yu S, Chuang K . Targeting the stromal androgen receptor in primary prostate tumors at earlier stages. Proc Natl Acad Sci U S A. 2008; 105(34):12188-93. PMC: 2527887. DOI: 10.1073/pnas.0804701105. View

10.

Fujimura T, Takahashi S, Urano T, Ogawa S, Ouchi Y, Kitamura T . Differential expression of estrogen receptor beta (ERbeta) and its C-terminal truncated splice variant ERbetacx as prognostic predictors in human prostatic cancer. Biochem Biophys Res Commun. 2001; 289(3):692-9. DOI: 10.1006/bbrc.2001.6038. View

11.

Lee H, Choe M . Expression of EZH2 in renal cell carcinoma as a novel prognostic marker. Pathol Int. 2012; 62(11):735-41. DOI: 10.1111/pin.12001. View

12.

Chiyomaru T, Fukuhara S, Saini S, Majid S, Deng G, Shahryari V . Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem. 2014; 289(18):12550-65. PMC: 4007447. DOI: 10.1074/jbc.M113.488593. View

13.

Kontovinis L, T Papazisis K, Touplikioti P, Andreadis C, Mouratidou D, Kortsaris A . Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: clinical outcomes and plasma angiogenesis markers. BMC Cancer. 2009; 9:82. PMC: 2662874. DOI: 10.1186/1471-2407-9-82. View

14.

Scher H, Sawyers C . Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol. 2005; 23(32):8253-61. DOI: 10.1200/JCO.2005.03.4777. View

15.

Siegel R, Miller K, Jemal A . Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1):7-30. DOI: 10.3322/caac.21387. View

16.

Powles T, Staehler M, Ljungberg B, Bensalah K, Canfield S, Dabestani S . European Association of Urology Guidelines for Clear Cell Renal Cancers That Are Resistant to Vascular Endothelial Growth Factor Receptor-Targeted Therapy. Eur Urol. 2016; 70(5):705-706. DOI: 10.1016/j.eururo.2016.06.009. View

17.

Zheng J, Li H, Zhu H, Xiao X, Ma Y . Genistein inhibits estradiol- and environmental endocrine disruptor-induced growth effects on neuroblastoma cells . Oncol Lett. 2013; 5(5):1583-1586. PMC: 3678847. DOI: 10.3892/ol.2013.1236. View

18.

Gibb E, Brown C, Lam W . The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011; 10:38. PMC: 3098824. DOI: 10.1186/1476-4598-10-38. View

19.

Xu Z, Zhang L, Gao B, Wan Y, Zhang X, Chen B . EZH2 promotes tumor progression by increasing VEGF expression in clear cell renal cell carcinoma. Clin Transl Oncol. 2014; 17(1):41-9. DOI: 10.1007/s12094-014-1195-5. View

20.

Sassen S, Miska E, Caldas C . MicroRNA: implications for cancer. Virchows Arch. 2007; 452(1):1-10. PMC: 2151131. DOI: 10.1007/s00428-007-0532-2. View