Icariin Promotes Wound Healing by Enhancing the Migration and Proliferation of Keratinocytes Via the AKT and ERK Signaling Pathway

Overview

Journal Int J Mol Med

Specialty Genetics

Date 2018 May 17

PMID 29767263

Citations 16

Authors

Bobin Mi

Jing Liu

Guohui Liu

Wu Zhou

Yi Liu

Liangcong Hu

Liming Xiong

Shunan Ye

Yongchao Wu

Affiliations

Soon will be listed here.

Abstract

Icariin is a traditional Chinese drug that has long been used to treat various diseases. In the present study, the effect of icariin was investigated on cutaneous wound healing. Using in vitro experiments, it was demonstrated that icariin significantly promoted the migration and proliferation of keratinocytes via the activation of AKT serine/threonine kinase 1 (AKT) and extracellular signal‑regulated kinase (ERK). Inhibition of AKT or ERK reversed the effects of icariin on the proliferation and migration of keratinocytes. In addition, icariin inhibited the production of interleukin (IL)‑6 and tumor necrosis factor (TNF)‑α and induced the production of IL‑10. Finally, animal experiments demonstrated that icariin treatment accelerated the wound closure rate. The present findings revealed that icariin may be a promising drug to promote the migration and proliferation of keratinocytes, and to accelerate the healing of skin wounds, through its role in the upregulation of AKT and ERK signaling.

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