T Cell Distribution is Different in Follicle-associated Epithelium of Human Peyer's Patches and Villous Epithelium

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1988 Nov 1

PMID 2975975

Citations 14

Authors

K Bjerke

P Brandtzaeg

O Fausa

Affiliations

Soon will be listed here.

Abstract

Immunohistochemical analyses performed on specimens of normal human ileum showed a significantly raised number of T cells in the follicle-associated epithelium (FAE) of Peyer's patches compared with the epithelium of distant villi. The T cells tended to be clustered in all layers of the FAE and were significantly more numerous adjacent to interruptions of the brush border (revealed by lack of staining for alkaline phosphatase). Such interruptions were taken to indicate 'membrane' (M) cells. Our findings therefore suggested a spatial relationship between M cells and the aggregation of T cells. The ratio of CD4+ to CD8+ T cells (approximately 4:10) was significantly higher in the FAE than in the villous epithelium (approximately 0.6:10). This suggested that the FAE may be involved to a greater extent in induction of 'helper' T cell functions, perhaps depending on luminal antigens transported by M cells, whereas the villous epithelium may be more involved in stimulation of 'suppressor' T cell functions as indicated by recent studies in vitro.

Citing Articles

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.

Morbe U, Jorgensen P, Fenton T, von Burg N, Riis L, Spencer J Mucosal Immunol. 2021; 14(4):793-802.

PMID: 33753873 DOI: 10.1038/s41385-021-00389-4.

Effects of the expansion of bacterial colonies into the intervillous spaces on the localization of several lymphocyte lineages in the rat ileum.

Yuasa H, Mantani Y, Miyamoto K, Nishida M, Arai M, Tsuruta H J Vet Med Sci. 2019; 81(4):555-566.

PMID: 30799326 PMC: 6483913. DOI: 10.1292/jvms.18-0734.

Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure.

Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S AIDS Res Hum Retroviruses. 2017; 33(S1):S40-S58.

PMID: 28882067 PMC: 5685216. DOI: 10.1089/AID.2017.0153.

Vimentin-positive cells in the epithelium of rabbit ileal villi represent cup cells but not M-cells.

Ramirez C, Gebert A J Histochem Cytochem. 2003; 51(11):1533-44.

PMID: 14566025 PMC: 3957562. DOI: 10.1177/002215540305101113.

Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivo.

Veazey R, Tham I, Mansfield K, Demaria M, Forand A, Shvetz D J Virol. 1999; 74(1):57-64.

PMID: 10590091 PMC: 111513. DOI: 10.1128/jvi.74.1.57-64.2000.

References

Bye W, Allan C, Trier J . Structure, distribution, and origin of M cells in Peyer's patches of mouse ileum. Gastroenterology. 1984; 86(5 Pt 1):789-801. View

Bjerke K, Brandtzaeg P . Lack of relation between expression of HLA-DR and secretory component (SC) in follicle-associated epithelium of human Peyer's patches. Clin Exp Immunol. 1988; 71(3):502-7. PMC: 1541660. View

Kaye P, Chain B, Feldmann M . Nonphagocytic dendritic cells are effective accessory cells for anti-mycobacterial responses in vitro. J Immunol. 1985; 134(3):1930-4. View

Kawanishi H, Ozato K, Strober W . The proliferative response of cloned Peyer's patch switch T cells to syngeneic and allogeneic stimuli. J Immunol. 1985; 134(6):3586-91. View

Huitfeldt H, Brandtzaeg P . Various keratin antibodies produce immunohistochemical staining of human myocardium and myometrium. Histochemistry. 1985; 83(5):381-9. DOI: 10.1007/BF00509196. View

Brandtzaeg P . Research in gastrointestinal immunology. State of the art. Scand J Gastroenterol Suppl. 1985; 114:137-56. DOI: 10.3109/00365528509093774. View

Kapsenberg M, Teunissen M, Stiekema F, Keizer H . Antigen-presenting cell function of dendritic cells and macrophages in proliferative T cell responses to soluble and particulate antigens. Eur J Immunol. 1986; 16(4):345-50. DOI: 10.1002/eji.1830160405. View

Hirata I, Berrebi G, Austin L, Keren D, DOBBINS 3rd W . Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease. Dig Dis Sci. 1986; 31(6):593-603. DOI: 10.1007/BF01318690. View

Bland P, WARREN L . Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera. Immunology. 1986; 58(1):1-7. PMC: 1452627. View

10.

Bland P, WARREN L . Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells. Immunology. 1986; 58(1):9-14. PMC: 1452640. View

11.

McClugage S, LOW F, Zimny M . Porosity of the basement membrane overlying Peyer's patches in rats and monkeys. Gastroenterology. 1986; 91(5):1128-33. DOI: 10.1016/s0016-5085(86)80007-5. View

12.

Faulk W, McCormick J, Goodman J, YOFFEY J, Fudenberg H . Peyer's patches: morphologic studies. Cell Immunol. 1970; 1(5):500-20. DOI: 10.1016/0008-8749(70)90038-9. View

13.

Ferguson A, Parrott D . The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse. Clin Exp Immunol. 1972; 12(4):477-88. PMC: 1553602. View

14.

Owen R, Jones A . Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles. Gastroenterology. 1974; 66(2):189-203. View

15.

Bockman D, Cooper M . Early lymphoepithelial relationships in human appendix. A combined light- and electron-microscopic study. Gastroenterology. 1975; 68(5 Pt 1):1160-8. View

16.

Owen R . Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study. Gastroenterology. 1977; 72(3):440-51. View

17.

Chu R, Glock R, Ross R . Gut-associated lymphoid tissues of young swine with emphasis on dome epithelium of aggregated lymph nodules (Peyer's patches) of the small intestine. Am J Vet Res. 1979; 40(12):1720-8. View

18.

Marsh M . Studies of intestinal lymphoid tissue. III. Quantitative analyses of epithelial lymphocytes in the small intestine of human control subjects and of patients with celiac sprue. Gastroenterology. 1980; 79(3):481-92. View

19.

Smith M, Jarvis L, King I . Cell proliferation in follicle-associated epithelium of mouse Peyer's patch. Am J Anat. 1980; 159(2):157-66. DOI: 10.1002/aja.1001590204. View

20.

Wolf J, Rubin D, Finberg R, Kauffman R, Sharpe A, Trier J . Intestinal M cells: a pathway for entry of reovirus into the host. Science. 1981; 212(4493):471-2. DOI: 10.1126/science.6259737. View