Antigen Presentation by Epithelial Cells of the Rat Small Intestine. I. Kinetics, Antigen Specificity and Blocking by Anti-Ia Antisera

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1986 May 1

PMID 2423435

Citations 74

Authors

P W Bland

L G WARREN

Affiliations

Soon will be listed here.

Abstract

Columnar epithelial cells (EC), isolated from the proximal small intestine of the rat, bind ovalbumin (OVA) by a non-specific, cold-inhibitable mechanism and continue to express Ia antigens after 24 hr culture in vitro. Lymph node T cells from rats immunized with OVA proliferate following 18 hr coculture with EC and OVA. This accessory cell function of EC is antigen-specific and is blocked by anti-Ia monoclonal antisera.

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