Human Metapneumovirus - What We Know Now

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2018 May 11

PMID 29744035

Citations 63

Authors

Nazly Shafagati

John Williams

Affiliations

Soon will be listed here.

Abstract

Human metapneumovirus (HMPV) is a leading cause of acute respiratory infection, particularly in children, immunocompromised patients, and the elderly. HMPV, which is closely related to avian metapneumovirus subtype C, has circulated for at least 65 years, and nearly every child will be infected with HMPV by the age of 5. However, immunity is incomplete, and re-infections occur throughout adult life. Symptoms are similar to those of other respiratory viral infections, ranging from mild (cough, rhinorrhea, and fever) to more severe (bronchiolitis and pneumonia). The preferred method for diagnosis is reverse transcription-polymerase chain reaction as HMPV is difficult to culture. Although there have been many advances made in the past 16 years since its discovery, there are still no US Food and Drug Administration-approved antivirals or vaccines available to treat HMPV. Both small animal and non-human primate models have been established for the study of HMPV. This review will focus on the epidemiology, transmission, and clinical manifestations in humans as well as the animal models of HMPV pathogenesis and host immune response.

Citing Articles

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References

Ren J, Kolli D, Deng J, Fang R, Gong B, Xue M . MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis. Virus Res. 2013; 176(1-2):241-50. PMC: 3819944. DOI: 10.1016/j.virusres.2013.06.014. View

Peret T, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus A . Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis. 2002; 185(11):1660-3. PMC: 7109943. DOI: 10.1086/340518. View

Pham Q, Biacchesi S, Skiadopoulos M, Murphy B, Collins P, Buchholz U . Chimeric recombinant human metapneumoviruses with the nucleoprotein or phosphoprotein open reading frame replaced by that of avian metapneumovirus exhibit improved growth in vitro and attenuation in vivo. J Virol. 2005; 79(24):15114-22. PMC: 1316028. DOI: 10.1128/JVI.79.24.15114-15122.2005. View

Juhasz K, Easton A . Extensive sequence variation in the attachment (G) protein gene of avian pneumovirus: evidence for two distinct subgroups. J Gen Virol. 1994; 75 ( Pt 11):2873-80. DOI: 10.1099/0022-1317-75-11-2873. View

Bosis S, Esposito S, Niesters H, Crovari P, Osterhaus A, Principi N . Impact of human metapneumovirus in childhood: comparison with respiratory syncytial virus and influenza viruses. J Med Virol. 2004; 75(1):101-4. DOI: 10.1002/jmv.20243. View

Kim H, Canchola J, BRANDT C, Pyles G, Chanock R, Jensen K . Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969; 89(4):422-34. DOI: 10.1093/oxfordjournals.aje.a120955. View

Corti D, Bianchi S, Vanzetta F, Minola A, Perez L, Agatic G . Cross-neutralization of four paramyxoviruses by a human monoclonal antibody. Nature. 2013; 501(7467):439-43. DOI: 10.1038/nature12442. View

Seal B . Matrix protein gene nucleotide and predicted amino acid sequence demonstrate that the first US avian pneumovirus isolate is distinct from European strains. Virus Res. 1999; 58(1-2):45-52. DOI: 10.1016/s0168-1702(98)00098-7. View

Tedcastle A, Fenwick F, Robinson M, Toms G . Immunogenicity in mice of human metapneumovirus with a truncated SH glycoprotein. J Med Virol. 2013; 86(4):547-57. DOI: 10.1002/jmv.23731. View

10.

Edwards K, Zhu Y, Griffin M, Weinberg G, Hall C, Szilagyi P . Burden of human metapneumovirus infection in young children. N Engl J Med. 2013; 368(7):633-43. PMC: 3662802. DOI: 10.1056/NEJMoa1204630. View

11.

van den Hoogen B, van Doornum G, Fockens J, Cornelissen J, Beyer W, de Groot R . Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis. 2003; 188(10):1571-7. DOI: 10.1086/379200. View

12.

Herd K, Mahalingam S, Mackay I, Nissen M, Sloots T, Tindle R . Cytotoxic T-lymphocyte epitope vaccination protects against human metapneumovirus infection and disease in mice. J Virol. 2006; 80(4):2034-44. PMC: 1367143. DOI: 10.1128/JVI.80.4.2034-2044.2006. View

13.

Adamson P, Thammawat S, Muchondo G, Sadlon T, Gordon D . Diversity in glycosaminoglycan binding amongst hMPV G protein lineages. Viruses. 2012; 4(12):3785-803. PMC: 3528290. DOI: 10.3390/v4123785. View

14.

Tollefson S, Cox R, Williams J . Studies of culture conditions and environmental stability of human metapneumovirus. Virus Res. 2010; 151(1):54-9. PMC: 2894476. DOI: 10.1016/j.virusres.2010.03.018. View

15.

Popowitch E, ONeill S, Miller M . Comparison of the Biofire FilmArray RP, Genmark eSensor RVP, Luminex xTAG RVPv1, and Luminex xTAG RVP fast multiplex assays for detection of respiratory viruses. J Clin Microbiol. 2013; 51(5):1528-33. PMC: 3647947. DOI: 10.1128/JCM.03368-12. View

16.

Williams J, Wang C, Yang C, Tollefson S, House F, Heck J . The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience. J Infect Dis. 2006; 193(3):387-95. PMC: 1586246. DOI: 10.1086/499274. View

17.

Piyaratna R, Tollefson S, Williams J . Genomic analysis of four human metapneumovirus prototypes. Virus Res. 2011; 160(1-2):200-5. PMC: 3347971. DOI: 10.1016/j.virusres.2011.06.014. View

18.

Haas L, Thijsen S, van Elden L, Heemstra K . Human metapneumovirus in adults. Viruses. 2013; 5(1):87-110. PMC: 3564111. DOI: 10.3390/v5010087. View

19.

Pavlin J, Hickey A, Ulbrandt N, Chan Y, Endy T, Boukhvalova M . Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein. J Infect Dis. 2008; 198(6):836-42. PMC: 2648801. DOI: 10.1086/591186. View

20.

Zhang Y, Wei Y, Zhang X, Cai H, Niewiesk S, Li J . Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase. J Virol. 2014; 88(19):11411-29. PMC: 4178811. DOI: 10.1128/JVI.00876-14. View