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Human Metapneumovirus in Adults

Overview
Journal Viruses
Publisher MDPI
Specialty Microbiology
Date 2013 Jan 10
PMID 23299785
Citations 41
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Abstract

Human metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001 and currently appears to be one of the most significant and common human viral infections. Retrospective serologic studies demonstrated the presence of HMPV antibodies in humans more than 50 years earlier. Although the virus was primarily known as causative agent of respiratory tract infections in children, HMPV is an important cause of respiratory infections in adults as well. Almost all children are infected by HMPV below the age of five; the repeated infections throughout life indicate transient immunity. HMPV infections usually are mild and self-limiting, but in the frail elderly and the immunocompromised patients, the clinical course can be complicated. Since culturing the virus is relatively difficult, diagnosis is mostly based on a nucleic acid amplification test, such as reverse transcriptase polymerase chain reaction. To date, no vaccine is available and treatment is supportive. However, ongoing research shows encouraging results. The aim of this paper is to review the current literature concerning HMPV infections in adults, and discuss recent development in treatment and vaccination.

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References
1.
Walsh E, Falsey A, Hennessey P . Respiratory syncytial and other virus infections in persons with chronic cardiopulmonary disease. Am J Respir Crit Care Med. 1999; 160(3):791-5. DOI: 10.1164/ajrccm.160.3.9901004. View

2.
Alvarez R, Elbashir S, Borland T, Toudjarska I, Hadwiger P, John M . RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy. Antimicrob Agents Chemother. 2009; 53(9):3952-62. PMC: 2737834. DOI: 10.1128/AAC.00014-09. View

3.
Falsey A, Criddle M, Walsh E . Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illness. J Clin Virol. 2005; 35(1):46-50. DOI: 10.1016/j.jcv.2005.04.004. View

4.
Walsh E, Peterson D, Falsey A . Human metapneumovirus infections in adults: another piece of the puzzle. Arch Intern Med. 2008; 168(22):2489-96. PMC: 2783624. DOI: 10.1001/archinte.168.22.2489. View

5.
Hamelin M, Boivin G . Development and validation of an enzyme-linked immunosorbent assay for human metapneumovirus serology based on a recombinant viral protein. Clin Diagn Lab Immunol. 2005; 12(2):249-53. PMC: 549303. DOI: 10.1128/CDLI.12.2.249-253.2005. View