Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging

Overview

Journal Sci Rep

Specialty Science

Date 2018 May 11

PMID 29743565

Citations 5

Authors

Kai Ruppert

Hooman Hamedani

Faraz Amzajerdian

Yi Xin

Ian F Duncan

Harrilla Profka

Sarmad Siddiqui

Mehrdad Pourfathi

Stephen Kadlecek

Rahim R Rizi

Affiliations

Soon will be listed here.

Abstract

Many forms of lung disease manifest themselves as pathological changes in the transport of gas to the circulatory system, yet the difficulty of imaging this process remains a central obstacle to the comprehensive diagnosis of lung disorders. Using hyperpolarized xenon-129 as a surrogate marker for oxygen, we derived the temporal dynamics of gas transport from the ratio of two lung images obtained with different timing parameters. Additionally, by monitoring changes in the total hyperpolarized xenon signal intensity in the left side of the heart induced by depletion of xenon signal in the alveolar airspaces of interest, we quantified the contributions of selected lung volumes to the total pulmonary gas transport. In a rabbit model, we found that it takes at least 200 ms for xenon gas to enter the lung tissue and travel the distance from the airspaces to the heart. Additionally, our method shows that both lungs contribute fairly equally to the gas transport in healthy rabbits, but that this ratio changes in a rabbit model of acid aspiration. These results suggest that hyperpolarized xenon-129 MRI may improve our ability to measure pulmonary gas transport and detect associated pathological changes.

Citing Articles

Regional variations in hyperpolarized 129Xe lung MRI: Insights from CSI-CSSR and CSSR in healthy and irradiated rat models.

Ruppert K, Loza L, Hamedani H, Ismail M, Chen J, Duncan I Magn Reson Med. 2024; 93(3):902-915.

PMID: 39503293 PMC: 11682931. DOI: 10.1002/mrm.30313.

Gas exchange and ventilation imaging of healthy and COPD subjects using hyperpolarized xenon-129 MRI and a 3D alveolar gas-exchange model.

Doganay O, Kim M, Gleeson F Eur Radiol. 2022; 33(5):3322-3331.

PMID: 36547671 DOI: 10.1007/s00330-022-09343-9.

Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI.

Ruppert K, Amzajerdian F, Xin Y, Hamedani H, Loza L, Achekzai T Magn Reson Med. 2020; 84(6):3027-3039.

PMID: 32557808 PMC: 8088830. DOI: 10.1002/mrm.28329.

Measurement of Regional 2D Gas Transport Efficiency in Rabbit Lung Using Hyperpolarized 129Xe MRI.

Ruppert K, Xin Y, Hamedani H, Amzajerdian F, Loza L, Achekzai T Sci Rep. 2019; 9(1):2413.

PMID: 30787357 PMC: 6382756. DOI: 10.1038/s41598-019-38942-8.

Imaging the Injured Lung: Mechanisms of Action and Clinical Use.

Cereda M, Xin Y, Goffi A, Herrmann J, Kaczka D, Kavanagh B Anesthesiology. 2019; 131(3):716-749.

PMID: 30664057 PMC: 6692186. DOI: 10.1097/ALN.0000000000002583.

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