Transcriptome Analysis in Whole Blood Reveals Increased Microbial Diversity in Schizophrenia

Overview

Journal Transl Psychiatry

Specialties Psychiatry
Public Health

Date 2018 May 11

PMID 29743478

Citations 49

Authors

Loes M Olde Loohuis

Serghei Mangul

Anil P S Ori

Guillaume Jospin

David Koslicki

Harry Taegyun Yang

Timothy Wu

Marco P Boks

Catherine Lomen-Hoerth

Martina Wiedau-Pazos

Rita M Cantor

Willem M de Vos

Rene S Kahn

Eleazar Eskin

Roel A Ophoff

Affiliations

Soon will be listed here.

Abstract

The role of the human microbiome in health and disease is increasingly appreciated. We studied the composition of microbial communities present in blood across 192 individuals, including healthy controls and patients with three disorders affecting the brain: schizophrenia, amyotrophic lateral sclerosis, and bipolar disorder. By using high-quality unmapped RNA sequencing reads as candidate microbial reads, we performed profiling of microbial transcripts detected in whole blood. We were able to detect a wide range of bacterial and archaeal phyla in blood. Interestingly, we observed an increased microbial diversity in schizophrenia patients compared to the three other groups. We replicated this finding in an independent schizophrenia case-control cohort. This increased diversity is inversely correlated with estimated cell abundance of a subpopulation of CD8 memory T cells in healthy controls, supporting a link between microbial products found in blood, immunity and schizophrenia.

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