Is There a Link Between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jan 21

PMID 35055031

Authors

Stanislas Martin

Audrey Foulon

Wissam El Hage

Diane Dufour-Rainfray

Frederic Denis

Affiliations

Soon will be listed here.

Abstract

The study aimed to examine the impact of the oropharyngeal microbiome in the pathophysiology of schizophrenia and to clarify whether there might be a bidirectional link between the oral microbiota and the brain in a context of dysbiosis-related neuroinflammation. We selected nine articles including three systemic reviews with several articles from the same research team. Different themes emerged, which we grouped into 5 distinct parts concerning the oropharyngeal phageome, the oropharyngeal microbiome, the salivary microbiome and periodontal disease potentially associated with schizophrenia, and the impact of drugs on the microbiome and schizophrenia. We pointed out the presence of phageoma in patients suffering from schizophrenia and that periodontal disease reinforces the role of inflammation in the pathophysiology of schizophrenia. Moreover, saliva could be an interesting substrate to characterize the different stages of schizophrenia. However, the few studies we have on the subject are limited in scope, and some of them are the work of a single team. At this stage of knowledge, it is difficult to conclude on the existence of a bidirectional link between the brain and the oral microbiome. Future studies on the subject will clarify these questions that for the moment remain unresolved.

Citing Articles

Oral Microbiome and Treatment Resistance Status in Schizophrenia: A Cross-sectional Study.

Sankaranarayanan A, Ramanathan P, Zakrzewski M, Vasani D, Ganapathy R, Brakoulias V Indian J Psychol Med. 2024; 47(1):97-99.

PMID: 39564305 PMC: 11572396. DOI: 10.1177/02537176241255725.

The critical intersection of mental health and oral health in severe mental disorders.

Jerjes W Clin Oral Investig. 2024; 28(11):627.

PMID: 39496980 DOI: 10.1007/s00784-024-06015-4.

Investigating the Impacts of Diet, Supplementation, Microbiota, Gut-Brain Axis on Schizophrenia: A Narrative Review.

Zajkowska I, Niczyporuk P, Urbaniak A, Tomaszek N, Modzelewski S, Waszkiewicz N Nutrients. 2024; 16(14).

PMID: 39064675 PMC: 11279812. DOI: 10.3390/nu16142228.

Genetically predicted causal associations between periodontitis and psychiatric disorders.

Tong S, Lyu Y, Huang W, Zeng R, Jiang R, Lian Q BMJ Ment Health. 2023; 26(1).

PMID: 37993283 PMC: 10668133. DOI: 10.1136/bmjment-2023-300864.

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions.

Hashimoto K Mol Psychiatry. 2023; 28(9):3625-3637.

PMID: 37845499 PMC: 10730413. DOI: 10.1038/s41380-023-02287-6.

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