Subthalamic Nucleus Deep Brain Stimulation Evokes Resonant Neural Activity

Overview

Journal Ann Neurol

Specialty Neurology

Date 2018 May 5

PMID 29727475

Citations 42

Authors

Nicholas C Sinclair

Hugh J McDermott

Kristian J Bulluss

James B Fallon

Thushara Perera

San San Xu

Peter Brown

Wesley Thevathasan

Affiliations

Soon will be listed here.

Abstract

Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes. Ann Neurol 2018;83:1027-1031.

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