Recruitment of Mitofusin 2 into "lipid Rafts" Drives Mitochondria Fusion Induced by Mdivi-1

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 May 4

PMID 29721168

Citations 11

Authors

Laura Ciarlo

Rosa Vona

Valeria Manganelli

Lucrezia Gambardella

Carla Raggi

Matteo Marconi

Walter Malorni

Maurizio Sorice

Tina Garofalo

Paola Matarrese

Affiliations

Soon will be listed here.

Abstract

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid "rafts" in mitochondrial morphogenetic changes and their homeostasis.

Citing Articles

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References

Cassidy-Stone A, Chipuk J, Ingerman E, Song C, Yoo C, Kuwana T . Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008; 14(2):193-204. PMC: 2267902. DOI: 10.1016/j.devcel.2007.11.019. View

George K, Wu S . Lipid raft: A floating island of death or survival. Toxicol Appl Pharmacol. 2012; 259(3):311-9. PMC: 3299927. DOI: 10.1016/j.taap.2012.01.007. View

Frazier A, Kiu C, Stojanovski D, Hoogenraad N, Ryan M . Mitochondrial morphology and distribution in mammalian cells. Biol Chem. 2006; 387(12):1551-8. DOI: 10.1515/BC.2006.193. View

Sorice M, Matarrese P, Tinari A, Giammarioli A, Garofalo T, Manganelli V . Raft component GD3 associates with tubulin following CD95/Fas ligation. FASEB J. 2009; 23(10):3298-308. DOI: 10.1096/fj.08-128140. View

Scorrano L . Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals?. J Cell Biol. 2008; 183(4):579-81. PMC: 2582901. DOI: 10.1083/jcb.200810125. View

Ranieri M, Brajkovic S, Riboldi G, Ronchi D, Rizzo F, Bresolin N . Mitochondrial fusion proteins and human diseases. Neurol Res Int. 2013; 2013:293893. PMC: 3678461. DOI: 10.1155/2013/293893. View

Marin-Garcia J, Akhmedov A . Mitochondrial dynamics and cell death in heart failure. Heart Fail Rev. 2016; 21(2):123-36. DOI: 10.1007/s10741-016-9530-2. View

Goyal G, Fell B, Sarin A, Youle R, Sriram V . Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Dev Cell. 2007; 12(5):807-16. PMC: 1885957. DOI: 10.1016/j.devcel.2007.02.002. View

Schon E, Przedborski S . Mitochondria: the next (neurode)generation. Neuron. 2011; 70(6):1033-53. PMC: 3407575. DOI: 10.1016/j.neuron.2011.06.003. View

10.

Del Dotto V, Mishra P, Vidoni S, Fogazza M, Maresca A, Caporali L . OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions. Cell Rep. 2017; 19(12):2557-2571. DOI: 10.1016/j.celrep.2017.05.073. View

11.

Wallace D . Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen. 2010; 51(5):440-50. DOI: 10.1002/em.20586. View

12.

Riemann D, Tcherkes A, Hansen G, Wulfaenger J, Blosz T, Danielsen E . Functional co-localization of monocytic aminopeptidase N/CD13 with the Fc gamma receptors CD32 and CD64. Biochem Biophys Res Commun. 2005; 331(4):1408-12. DOI: 10.1016/j.bbrc.2005.04.061. View

13.

Li Y, Wang M, Wang S . Effect of inhibiting mitochondrial fission on energy metabolism in rat hippocampal neurons during ischemia/reperfusion injury. Neurol Res. 2019; 38(11):1027-1034. DOI: 10.1080/01616412.2016.1215050. View

14.

Skibbens J, Roth M, Matlin K . Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts. J Cell Biol. 1989; 108(3):821-32. PMC: 2115377. DOI: 10.1083/jcb.108.3.821. View

15.

Frank S, Gaume B, Bergmann-Leitner E, Leitner W, Robert E, Catez F . The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell. 2001; 1(4):515-25. DOI: 10.1016/s1534-5807(01)00055-7. View

16.

James D, Parone P, Mattenberger Y, Martinou J . hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem. 2003; 278(38):36373-9. DOI: 10.1074/jbc.M303758200. View

17.

Pitts K, McNiven M, Yoon Y . Mitochondria-specific function of the dynamin family protein DLP1 is mediated by its C-terminal domains. J Biol Chem. 2004; 279(48):50286-94. DOI: 10.1074/jbc.M405531200. View

18.

Rambold A, Kostelecky B, Elia N, Lippincott-Schwartz J . Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A. 2011; 108(25):10190-5. PMC: 3121813. DOI: 10.1073/pnas.1107402108. View

19.

Twig G, Elorza A, Molina A, Mohamed H, Wikstrom J, Walzer G . Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008; 27(2):433-46. PMC: 2234339. DOI: 10.1038/sj.emboj.7601963. View

20.

Lee H, Yoon Y . Mitochondrial fission and fusion. Biochem Soc Trans. 2016; 44(6):1725-1735. DOI: 10.1042/BST20160129. View