Motor Proteins

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2018 May 3

PMID 29716949

Citations 90

Authors

H Lee Sweeney

Erika L F Holzbaur

Affiliations

Soon will be listed here.

Abstract

Myosin motors power movements on actin filaments, whereas dynein and kinesin motors power movements on microtubules. The mechanisms of these motor proteins differ, but, in all cases, ATP hydrolysis and subsequent release of the hydrolysis products drives a cycle of interactions with the track (either an actin filament or a microtubule), resulting in force generation and directed movement.

Citing Articles

Nano-Scale Video Imaging of Motility Machinery by High-Speed Atomic Force Microscopy.

McArthur S, Umeda K, Kodera N Biomolecules. 2025; 15(2).

PMID: 40001560 PMC: 11852755. DOI: 10.3390/biom15020257.

On-Demand Photoactivation of DNA-Based Motor Motion.

Piranej S, Ogasawara H, Zhang L, Jackson K, Bazrafshan A, Salaita K ACS Nano. 2025; 19(5):5363-5375.

PMID: 39883883 PMC: 11823613. DOI: 10.1021/acsnano.4c13068.

Myelinated Glial Cells: Their Proposed Role in Waste Clearance and Neurodegeneration in Arachnid and Human Brain.

Fabian-Fine R, Weaver A, Roman A, Winters M, DeWitt J J Comp Neurol. 2024; 532(11):e70000.

PMID: 39610046 PMC: 11605019. DOI: 10.1002/cne.70000.

DNA-Regulated Multi-Protein Complement Control.

Ma Y, Winegar P, Figg C, Ramani N, Anderson A, Ngo K J Am Chem Soc. 2024; 146(48):32912-32918.

PMID: 39569872 PMC: 11755408. DOI: 10.1021/jacs.4c11315.

Molecular Motors in Myelination and Their Misregulation in Disease.

Barbosa D, Carvalho C, Costa I, Silva R Mol Neurobiol. 2024; 62(4):4705-4723.

PMID: 39477877 PMC: 11880050. DOI: 10.1007/s12035-024-04576-9.

References

Varga V, Helenius J, Tanaka K, Hyman A, Tanaka T, Howard J . Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat Cell Biol. 2006; 8(9):957-62. DOI: 10.1038/ncb1462. View

Rice S, Lin A, Safer D, Hart C, Naber N, Carragher B . A structural change in the kinesin motor protein that drives motility. Nature. 2000; 402(6763):778-84. DOI: 10.1038/45483. View

Whittaker M, Smith J, Faust L, Milligan R, Sweeney H . A 35-A movement of smooth muscle myosin on ADP release. Nature. 1995; 378(6558):748-51. DOI: 10.1038/378748a0. View

Gee M, Heuser J, Vallee R . An extended microtubule-binding structure within the dynein motor domain. Nature. 1997; 390(6660):636-9. DOI: 10.1038/37663. View

DeWitt M, Chang A, Combs P, Yildiz A . Cytoplasmic dynein moves through uncoordinated stepping of the AAA+ ring domains. Science. 2011; 335(6065):221-5. PMC: 4033606. DOI: 10.1126/science.1215804. View

Scholey J . Kinesin-2: a family of heterotrimeric and homodimeric motors with diverse intracellular transport functions. Annu Rev Cell Dev Biol. 2013; 29:443-69. DOI: 10.1146/annurev-cellbio-101512-122335. View

Vale R, Reese T, Sheetz M . Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell. 1985; 42(1):39-50. PMC: 2851632. DOI: 10.1016/s0092-8674(85)80099-4. View

Clancy B, Behnke-Parks W, Andreasson J, Rosenfeld S, Block S . A universal pathway for kinesin stepping. Nat Struct Mol Biol. 2011; 18(9):1020-7. PMC: 3167932. DOI: 10.1038/nsmb.2104. View

Roberts A, Malkova B, Walker M, Sakakibara H, Numata N, Kon T . ATP-driven remodeling of the linker domain in the dynein motor. Structure. 2012; 20(10):1670-80. PMC: 3469822. DOI: 10.1016/j.str.2012.07.003. View

10.

Laan L, Pavin N, Husson J, Romet-Lemonne G, van Duijn M, Lopez M . Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell. 2012; 148(3):502-14. PMC: 3292199. DOI: 10.1016/j.cell.2012.01.007. View

11.

Herrmann H, Aebi U . Intermediate Filaments: Structure and Assembly. Cold Spring Harb Perspect Biol. 2016; 8(11). PMC: 5088526. DOI: 10.1101/cshperspect.a018242. View

12.

Gibbons I, Mocz G, Phillipson C, Tang W, GIBBONS B . Photosensitized cleavage of dynein heavy chains. Cleavage at the "V1 site" by irradiation at 365 nm in the presence of ATP and vanadate. J Biol Chem. 1987; 262(6):2780-6. View

13.

Tyska M, Warshaw D . The myosin power stroke. Cell Motil Cytoskeleton. 2002; 51(1):1-15. DOI: 10.1002/cm.10014. View

14.

Kull F, Sablin E, Lau R, Fletterick R, Vale R . Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 1996; 380(6574):550-5. PMC: 2851642. DOI: 10.1038/380550a0. View

15.

Espindola F, Suter D, Partata L, Cao T, Wolenski J, Cheney R . The light chain composition of chicken brain myosin-Va: calmodulin, myosin-II essential light chains, and 8-kDa dynein light chain/PIN. Cell Motil Cytoskeleton. 2000; 47(4):269-81. DOI: 10.1002/1097-0169(200012)47:4<269::AID-CM2>3.0.CO;2-G. View

16.

Phichith D, Travaglia M, Yang Z, Liu X, Zong A, Safer D . Cargo binding induces dimerization of myosin VI. Proc Natl Acad Sci U S A. 2009; 106(41):17320-4. PMC: 2753641. DOI: 10.1073/pnas.0909748106. View

17.

Sweeney H, Houdusse A . Myosin VI rewrites the rules for myosin motors. Cell. 2010; 141(4):573-82. DOI: 10.1016/j.cell.2010.04.028. View

18.

Ross J, Wallace K, Shuman H, Goldman Y, Holzbaur E . Processive bidirectional motion of dynein-dynactin complexes in vitro. Nat Cell Biol. 2006; 8(6):562-70. DOI: 10.1038/ncb1421. View

19.

Leube R, Moch M, Windoffer R . Intracellular Motility of Intermediate Filaments. Cold Spring Harb Perspect Biol. 2017; 9(6). PMC: 5453390. DOI: 10.1101/cshperspect.a021980. View

20.

Wells A, Lin A, Chen L, Safer D, CAIN S, Hasson T . Myosin VI is an actin-based motor that moves backwards. Nature. 1999; 401(6752):505-8. DOI: 10.1038/46835. View