Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2018 May 2

PMID 29711420

Citations 155

Authors

Helen E Blackwell

Robert H Grubbs

Affiliations

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Abstract

Olefin metathesis has been successfully applied to the synthesis of macrocyclic helical peptides [Eq. (a)]. Carbon-carbon bond tethers between amino acid side chains were introduced by ring-closing metathesis. This macrocyclization protocol is a novel and mild procedure for introducing nonnative covalent cross-links into peptide helices.

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