Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy Effect and T MRI Contrast in Liver Cell Lines

Overview

Journal Sci Rep

Specialty Science

Date 2018 Apr 29

PMID 29703912

Citations 19

Authors

Krungchanuchat Saowalak

Thongtem Titipun

Thongtem Somchai

Pilapong Chalermchai

Affiliations

Soon will be listed here.

Abstract

Herein, a new molecular nanoparticle based on iron(III)-tannic complexes (Fe-TA NPs) is presented. The Fe-TA NPs were simply obtained by mixing the precursors in a buffered solution at room temperature, and they exhibited good physicochemical properties with capability of inducing autophagy in both hepatocellular carcinoma cells (HepG2.2.15) and normal rat hepatocytes (AML12). The Fe-TA NPs were found to induce HepG2.2.15 cell death via autophagic cell death but have no effect on cell viability in AML12 cells. This is possibly due to the much higher uptake of the Fe-TA NPs by the HepG2.2.15 cells via the receptor-mediated endocytosis pathway. As a consequence, enhancement of the T MRI contrast was clearly observed in the HepG2.2.15 cells. The results demonstrate that the Fe-TA NPs could provide a new strategy combining diagnostic and therapeutic functions for hepatocellular carcinoma. Additionally, because of their autophagy-inducing properties, they can be applied as autophagy enhancers for prevention and treatment of other diseases.

Citing Articles

Nanofiltration Membranes Containing a Metal-Polyphenol Network Layer: Using Casting Solution pH as a Tool to Tailor the Separation Performance.

Kinfu H, Rahman M, Cevallos-Cueva N, Abetz V ACS Omega. 2024; 9(46):45870-45883.

PMID: 39583717 PMC: 11579772. DOI: 10.1021/acsomega.4c04804.

Unravelling the physicochemical and antimicrobial mechanisms of human serum albumin/tannic acid coatings for medical-grade polycaprolactone scaffolds.

Cometta S, Donose B, Juarez-Saldivar A, Ravichandran A, Xu Y, Bock N Bioact Mater. 2024; 42:68-84.

PMID: 39280579 PMC: 11399811. DOI: 10.1016/j.bioactmat.2024.08.023.

Chemistry, biosynthesis, and theranostics of antioxidant flavonoids and polyphenolics of genus Rhododendron: an overview.

Hussain A, Azam S, Maqsood R, Anwar R, Akash M, Hussain H Naunyn Schmiedebergs Arch Pharmacol. 2024; 398(2):1171-1214.

PMID: 39276249 DOI: 10.1007/s00210-024-03428-6.

The impact of nanomaterials on autophagy across health and disease conditions.

Florance I, Cordani M, Pashootan P, Moosavi M, Zarrabi A, Chandrasekaran N Cell Mol Life Sci. 2024; 81(1):184.

PMID: 38630152 PMC: 11024050. DOI: 10.1007/s00018-024-05199-y.

Tannic acid-mediated synthesis of flower-like mesoporous MnO nanostructures as T-T dual-modal MRI contrast agents and dual-enzyme mimetic agents.

Sorouri F, Gholibegloo E, Mortezazadeh T, Kiani S, Foroumadi A, Firoozpour L Sci Rep. 2023; 13(1):14606.

PMID: 37670132 PMC: 10480446. DOI: 10.1038/s41598-023-41598-0.

References

Huang D, Zhou H, Gao J . Nanoparticles modulate autophagic effect in a dispersity-dependent manner. Sci Rep. 2015; 5:14361. PMC: 4585824. DOI: 10.1038/srep14361. View

Eskelinen E, Saftig P . Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta. 2008; 1793(4):664-73. DOI: 10.1016/j.bbamcr.2008.07.014. View

Boland B, Kumar A, Lee S, Platt F, Wegiel J, Yu W . Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci. 2008; 28(27):6926-37. PMC: 2676733. DOI: 10.1523/JNEUROSCI.0800-08.2008. View

Holten-Andersen N, Harrington M, Birkedal H, Lee B, Messersmith P, Lee K . pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli. Proc Natl Acad Sci U S A. 2011; 108(7):2651-5. PMC: 3041094. DOI: 10.1073/pnas.1015862108. View

Liu Y, Ma K, Jiao T, Xing R, Shen G, Yan X . Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy. Sci Rep. 2017; 7:42978. PMC: 5322353. DOI: 10.1038/srep42978. View

Lian J, Wu X, He F, Karnak D, Tang W, Meng Y . A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ. 2010; 18(1):60-71. PMC: 2950895. DOI: 10.1038/cdd.2010.74. View

Steeves M, Dorsey F, Cleveland J . Targeting the autophagy pathway for cancer chemoprevention. Curr Opin Cell Biol. 2010; 22(2):218-25. PMC: 2854265. DOI: 10.1016/j.ceb.2009.12.013. View

Phillip J, Wu P, Gilkes D, Williams W, McGovern S, Daya J . Biophysical and biomolecular determination of cellular age in humans. Nat Biomed Eng. 2019; 1(7). PMC: 6675017. DOI: 10.1038/s41551-017-0093. View

Glick D, Barth S, Macleod K . Autophagy: cellular and molecular mechanisms. J Pathol. 2010; 221(1):3-12. PMC: 2990190. DOI: 10.1002/path.2697. View

10.

Tavera-Mendoza L, Westerling T, Libby E, Marusyk A, Cato L, Cassani R . Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017; 114(11):E2186-E2194. PMC: 5358377. DOI: 10.1073/pnas.1615015114. View

11.

De Leon-Rodriguez L, Martins A, Pinho M, Rofsky N, Sherry A . Basic MR relaxation mechanisms and contrast agent design. J Magn Reson Imaging. 2015; 42(3):545-65. PMC: 4537356. DOI: 10.1002/jmri.24787. View

12.

Kwon H, Kim J, Kim B, Srivastava S, Kim S . Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells. Arch Toxicol. 2017; 92(1):241-257. DOI: 10.1007/s00204-017-2021-y. View

13.

Tsujimoto Y, Shimizu S . Another way to die: autophagic programmed cell death. Cell Death Differ. 2005; 12 Suppl 2:1528-34. DOI: 10.1038/sj.cdd.4401777. View

14.

Pisco A, Huang S . Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: 'What does not kill me strengthens me'. Br J Cancer. 2015; 112(11):1725-32. PMC: 4647245. DOI: 10.1038/bjc.2015.146. View

15.

Kim S, Kim D, Kang S . Reversible layer-by-layer deposition on solid substrates inspired by mussel byssus cuticle. Chem Asian J. 2013; 9(1):63-6. DOI: 10.1002/asia.201301291. View

16.

Tan C, Yu J, Tan M, Jiang T, Zhu X, Tan L . Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy. Neurobiol Aging. 2013; 35(5):941-57. DOI: 10.1016/j.neurobiolaging.2013.11.019. View

17.

Krungchanuchat S, Thongtem T, Thongtem S, Pilapong C . Characterization and cellular studies of molecular nanoparticle of iron (III)-tannic complexes; toward a low cost magnetic resonance imaging agent. Biointerphases. 2017; 12(2):021005. DOI: 10.1116/1.4985002. View

18.

Xing R, Jiao T, Liu Y, Ma K, Zou Q, Ma G . Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy. Polymers (Basel). 2019; 8(5). PMC: 6431907. DOI: 10.3390/polym8050181. View

19.

Phiwchai I, Yuensook W, Sawaengsiriphon N, Krungchanuchat S, Pilapong C . Tannic acid (TA): A molecular tool for chelating and imaging labile iron. Eur J Pharm Sci. 2017; 114:64-73. DOI: 10.1016/j.ejps.2017.12.004. View

20.

Ling D, Park W, Park S, Lu Y, Kim K, Hackett M . Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors. J Am Chem Soc. 2014; 136(15):5647-55. DOI: 10.1021/ja4108287. View