» Articles » PMID: 29703232

Effects of Mesenchymal Stem Cells on Solid Tumor Metastasis in Experimental Cancer Models: a Systematic Review and Meta-analysis

Overview
Journal J Transl Med
Publisher Biomed Central
Date 2018 Apr 29
PMID 29703232
Citations 15
Authors
Affiliations
Soon will be listed here.
Abstract

Background: It has been reported mesenchymal stem cells (MSCs) are recruited to and become integral parts of the tumor microenvironment. MSCs might have an active role in solid tumor progression, especially cancer metastasis. However, the contribution of MSCs in the process of cancer metastasis is still controversial. In this review, we performed a meta-analysis on the effects of MSCs administration on cancer metastasis based on published preclinical studies.

Methods: The PRISMA guidelines were used. A total of 42 publications met the inclusion criteria. Outcome data on the incidence and the number of cancer metastasis as well as study characteristics were extracted. Quality of the studies was assessed according to SYRCLE Risk of Bias tool. Random-effects meta-analysis was used to pool estimates.

Results: Of the 42 studies included, 32 reported that MSCs administration promoted outcome events (numbers or incidences of cancer metastasis), and 39 reported data suitable for meta-analysis. The median effect size (RR) was 2.04 for the incidence of cancer metastasis (95% CI 1.57-2.65, I = 21%), and the median effect size (SMD) was 1.23 for the number of cancer metastasis (95% CI 0.43-2.03, I = 89%). Heterogeneity was observed, with the greater impact based on study length and different ways of metastasis measurement and MSCs administration.

Conclusion: Our results suggested MSCs administration increased the number and the incidence of cancer metastasis in experimental cancer models. High heterogeneity and poor reported risk of bias limit the quality of these findings. Further preclinical studies with better design and adequate reporting are still needed.

Citing Articles

Non-coding RNAs secreted by renal cancer include piR_004153 that promotes migration of mesenchymal stromal cells.

Boguslawska J, Grzanka M, Poplawski P, Zarychta-Wisniewska W, Burdzinska A, Hanusek K Cell Commun Signal. 2025; 23(1):3.

PMID: 39754169 PMC: 11697636. DOI: 10.1186/s12964-024-02001-1.


Molecular and cellular mechanisms of chemoresistance in paediatric pre-B cell acute lymphoblastic leukaemia.

Lill C, Fitter S, Zannettino A, Vandyke K, Noll J Cancer Metastasis Rev. 2024; 43(4):1385-1399.

PMID: 39102101 PMC: 11554931. DOI: 10.1007/s10555-024-10203-9.


The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways.

Bakhtiyari M, Liaghat M, Aziziyan F, Shapourian H, Yahyazadeh S, Alipour M Cell Commun Signal. 2023; 21(1):252.

PMID: 37735675 PMC: 10512514. DOI: 10.1186/s12964-023-01282-2.


Application of mesenchymal stem cells for anti-senescence and clinical challenges.

Wang Y, Gao T, Wang B Stem Cell Res Ther. 2023; 14(1):260.

PMID: 37726805 PMC: 10510299. DOI: 10.1186/s13287-023-03497-z.


Renal cancer secretome induces migration of mesenchymal stromal cells.

Poplawski P, Zarychta-Wisniewska W, Burdzinska A, Boguslawska J, Adamiok-Ostrowska A, Hanusek K Stem Cell Res Ther. 2023; 14(1):200.

PMID: 37563650 PMC: 10413545. DOI: 10.1186/s13287-023-03430-4.


References
1.
Fan W, Li J, Wang Y, Pan J, Li S, Zhu L . CD105 promotes chondrogenesis of synovium-derived mesenchymal stem cells through Smad2 signaling. Biochem Biophys Res Commun. 2016; 474(2):338-344. DOI: 10.1016/j.bbrc.2016.04.101. View

2.
Ma F, Chen D, Chen F, Chi Y, Han Z, Feng X . Human Umbilical Cord Mesenchymal Stem Cells Promote Breast Cancer Metastasis by Interleukin-8- and Interleukin-6-Dependent Induction of CD44(+)/CD24(-) Cells. Cell Transplant. 2015; 24(12):2585-99. DOI: 10.3727/096368915X687462. View

3.
Luo J, Ok Lee S, Liang L, Huang C, Li L, Wen S . Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling. Oncogene. 2013; 33(21):2768-78. DOI: 10.1038/onc.2013.233. View

4.
Carnet O, Lecomte J, Masset A, Primac I, Durre T, Maertens L . Mesenchymal Stem Cells Shed Amphiregulin at the Surface of Lung Carcinoma Cells in a Juxtacrine Manner. Neoplasia. 2015; 17(7):552-63. PMC: 4547406. DOI: 10.1016/j.neo.2015.07.002. View

5.
Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Watanabe T . CD90+ mesothelial-like cells in peritoneal fluid promote peritoneal metastasis by forming a tumor permissive microenvironment. PLoS One. 2014; 9(1):e86516. PMC: 3897715. DOI: 10.1371/journal.pone.0086516. View