Glycodelin in Reproduction

Overview

Journal Reprod Med Biol

Specialty Biology

Date 2018 Apr 28

PMID 29699134

Citations 13

Authors

Hiroshi Uchida

Tetsuo Maruyama

Sayaka Nishikawa-Uchida

Kaoru Miyazaki

Hirotaka Masuda

Yasunori Yoshimura

Affiliations

Soon will be listed here.

Abstract

To achieve a successful pregnancy in humans, sperm is required for capacitation, followed by binding to and entry into an oocyte. Maternal endometrial epithelial cells (EECs) prepare the appropriate implantation environment through regulation of immune cells and endometrial cells. After acquiring endometrial receptivity, a successful pregnancy consists of complex and finely regulated steps involving apposition, adhesion, invasion, and penetration. Glycodelin is a secretory glycoprotein that affects cell proliferation, differentiation, adhesion, and motility. Glycodelin has four glycoforms (glycodelin-A, -S, -F. and -C); differences in glycosylation affect each characteristic function. Glycodelin has a unique temporospatial pattern of expression, primarily in the reproductive tract where glycodelin is mid-secretory phase-dominant. Recent studies have demonstrated that glycodelin protein has the potential to regulate various processes, including immunosuppression, fertilization, and implantation. This review details the orchestrated regulation of successful pregnancy by glycodelin as well as a discussion of the basic characteristics of glycodelin.

Citing Articles

Expression of Endometrial Receptivity Markers throughout the Menstrual Cycle in Women with and without Uterine Adenomyosis.

Stratopoulou C, El Grari I, Camboni A, Donnez J, Dolmans M J Clin Med. 2024; 13(17).

PMID: 39274229 PMC: 11395822. DOI: 10.3390/jcm13175016.

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank.

Hillary R, Gadd D, Kuncheva Z, Mangelis T, Lin T, Ferber K Nat Commun. 2024; 15(1):7346.

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Molecular Determinants of Uterine Receptivity: Comparison of Successful Implantation, Recurrent Miscarriage, and Recurrent Implantation Failure.

Gunther V, Allahqoli L, Deenadayal-Mettler A, Maass N, Mettler L, Gitas G Int J Mol Sci. 2023; 24(24).

PMID: 38139443 PMC: 10743587. DOI: 10.3390/ijms242417616.

Polycystic ovary syndrome and recurrent pregnancy loss, a review of literature.

Wartena R, Matjila M Front Endocrinol (Lausanne). 2023; 14:1183060.

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Endometrial fluid biomarkers and their potential as predictors of successful embryo implantation.

Alves A, Dias M, Silvestre M Biomedicine (Taipei). 2023; 13(3):1-8.

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