Novel Activities of Safe-in-human Broad-spectrum Antiviral Agents

Overview

Journal Antiviral Res

Publisher Elsevier

Date 2018 Apr 27

PMID 29698664

Citations 37

Authors

Aleksandr Ianevski

Eva Zusinaite

Suvi Kuivanen

Marten Strand

Hilde Lysvand

Mona Teppor

Laura Kakkola

Henrik Paavilainen

Mira Laajala

Hannimari Kallio-Kokko

Miia Valkonen

Anu Kantele

Kaidi Telling

Irja Lutsar

Pille Letjuka

Natalja Metelitsa

Valentyn Oksenych

Magnar Bjoras

Svein Arne Nordbo

Uga Dumpis

Astra Vitkauskiene

Christina Ohrmalm

Kare Bondeson

Anders Bergqvist

Tero Aittokallio

Rebecca J Cox

Magnus Evander

Veijo Hukkanen

Varpu Marjomaki

Ilkka Julkunen

Olli Vapalahti

Tanel Tenson

Andres Merits

Denis Kainov

Affiliations

Soon will be listed here.

Abstract

According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.

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