Put "gender Glasses" on the Effects of Phenolic Compounds on Cardiovascular Function and Diseases

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2018 Apr 27

PMID 29696400

Citations 25

Authors

Ilaria Campesi

Maria Marino

Manuela Cipolletti

Annalisa Romani

Flavia Franconi

Affiliations

Soon will be listed here.

Abstract

Introduction: The influence of sex and gender is particularly relevant in cardiovascular diseases (CVD) as well as in several aspects of drug pharmacodynamics and pharmacokinetics. Anatomical and physiological differences between the sexes may influence the activity of many drugs, including the possibility of their interaction with other drugs, bioactive compounds, foods and beverages. Phenolic compounds could interact with our organism at organ, cellular, and molecular levels triggering a preventive action against chronic diseases, including CVD.

Results: This article will review the role of sex on the activity of these bioactive molecules, considering the existence of sex differences in oxidative stress. It describes the pharmacokinetics of phenolic compounds, their effects on vessels, on cardiovascular system, and during development, including the role of nuclear receptors and microbiota.

Conclusions: Although there is a large gap between the knowledge of the sex differences in the phenolic compounds' activity and safety, and the urgent need for more research, available data underlie the possibility that plant-derived phenolic compounds could differently influence the health of male and female subjects.

Citing Articles

Possible Beneficial Effects of Hydrolyzable Tannins Deriving from L. in Internal Medicine.

Marrone G, Di Lauro M, Izzo F, Cornali K, Masci C, Vita C Nutrients. 2024; 16(1).

PMID: 38201875 PMC: 10780656. DOI: 10.3390/nu16010045.

The Impact of Sex and Gender in Medicine and Pharmacology.

Becher E, Oertelt-Prigione S Handb Exp Pharmacol. 2023; 282:3-23.

PMID: 37594607 DOI: 10.1007/164_2023_688.

Dietary Antioxidants, Quality of Nutrition and Cardiovascular Characteristics among Omnivores, Flexitarians and Vegetarians in Poland-The Results of Multicenter National Representative Survey WOBASZ.

Kwasniewska M, Pikala M, Grygorczuk O, Waskiewicz A, Stepaniak U, Pajak A Antioxidants (Basel). 2023; 12(2).

PMID: 36829779 PMC: 9952668. DOI: 10.3390/antiox12020222.

Changes in food during the COVID-19 pandemic: The different roles of stress and depression in women and men.

Coppi F, Farinetti A, Stefanelli C, Mattioli A Nutrition. 2023; 108:111981.

PMID: 36804282 PMC: 9883207. DOI: 10.1016/j.nut.2023.111981.

Sex Differences in X-ray-Induced Endothelial Damage: Effect of Taurine and N-Acetylcysteine.

Campesi I, Brunetti A, Capobianco G, Galistu A, Montella A, Ieri F Antioxidants (Basel). 2023; 12(1).

PMID: 36670939 PMC: 9854489. DOI: 10.3390/antiox12010077.

References

Franconi F, Rosano G, Basili S, Montella A, Campesi I . Human cells involved in atherosclerosis have a sex. Int J Cardiol. 2016; 228:983-1001. DOI: 10.1016/j.ijcard.2016.11.118. View

Jaiswal A . Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med. 2004; 36(10):1199-207. DOI: 10.1016/j.freeradbiomed.2004.02.074. View

Strassburg C, Kalthoff S, Ehmer U . Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A). Crit Rev Clin Lab Sci. 2008; 45(6):485-530. DOI: 10.1080/10408360802374624. View

Ritchie R, Drummond G, Sobey C, De Silva T, Kemp-Harper B . The opposing roles of NO and oxidative stress in cardiovascular disease. Pharmacol Res. 2016; 116:57-69. DOI: 10.1016/j.phrs.2016.12.017. View

Usui T, Tochiya M, Sasaki Y, Muranaka K, Yamakage H, Himeno A . Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status. Clin Endocrinol (Oxf). 2012; 78(3):365-72. DOI: 10.1111/j.1365-2265.2012.04400.x. View

Li S, Liu X, Bai Y, Wang X, Sun K, Chen J . Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials. Am J Clin Nutr. 2009; 91(2):480-6. DOI: 10.3945/ajcn.2009.28203. View

Ho S, Woo J, Leung S, Sham A, Lam T, Janus E . Intake of soy products is associated with better plasma lipid profiles in the Hong Kong Chinese population. J Nutr. 2000; 130(10):2590-3. DOI: 10.1093/jn/130.10.2590. View

Alissa E, Ferns G . Dietary fruits and vegetables and cardiovascular diseases risk. Crit Rev Food Sci Nutr. 2015; 57(9):1950-1962. DOI: 10.1080/10408398.2015.1040487. View

Monostory K, Pascussi J, Kobori L, Dvorak Z . Hormonal regulation of CYP1A expression. Drug Metab Rev. 2009; 41(4):547-72. DOI: 10.1080/03602530903112284. View

10.

Egert S, Bosy-Westphal A, Seiberl J, Kurbitz C, Settler U, Plachta-Danielzik S . Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009; 102(7):1065-74. DOI: 10.1017/S0007114509359127. View

11.

Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H . Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A. 2008; 105(6):2117-22. PMC: 2538887. DOI: 10.1073/pnas.0712038105. View

12.

Markle J, Frank D, Mortin-Toth S, Robertson C, Feazel L, Rolle-Kampczyk U . Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science. 2013; 339(6123):1084-8. DOI: 10.1126/science.1233521. View

13.

Lemire J, Alhasawi A, Appanna V, Tharmalingam S, Appanna V . Metabolic defence against oxidative stress: the road less travelled so far. J Appl Microbiol. 2017; 123(4):798-809. DOI: 10.1111/jam.13509. View

14.

Mueller S, Saunier K, Hanisch C, Norin E, Alm L, Midtvedt T . Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol. 2006; 72(2):1027-33. PMC: 1392899. DOI: 10.1128/AEM.72.2.1027-1033.2006. View

15.

Dai G, He L, Chou N, Wan Y . Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse. Toxicol Sci. 2006; 92(1):33-41. DOI: 10.1093/toxsci/kfj192. View

16.

Brunelli E, Domanico F, La Russa D, Pellegrino D . Sex differences in oxidative stress biomarkers. Curr Drug Targets. 2014; 15(8):811-5. DOI: 10.2174/1389450115666140624112317. View

17.

Li Y, Ross-Viola J, Shay N, Moore D, Ricketts M . Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. J Nutr. 2009; 139(5):898-904. PMC: 2714390. DOI: 10.3945/jn.108.103572. View

18.

Mennen L, Sapinho D, de Bree A, Arnault N, Bertrais S, Galan P . Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women. J Nutr. 2004; 134(4):923-6. DOI: 10.1093/jn/134.4.923. View

19.

Fortepiani L, Reckelhoff J . Role of oxidative stress in the sex differences in blood pressure in spontaneously hypertensive rats. J Hypertens. 2005; 23(4):801-5. DOI: 10.1097/01.hjh.0000163149.05083.13. View

20.

Kander M, Cui Y, Liu Z . Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases. J Cell Mol Med. 2016; 21(5):1024-1032. PMC: 5387169. DOI: 10.1111/jcmm.13038. View