Generation of Germ Cells from Pluripotent Stem Cells in Mammals

Overview

Journal Reprod Med Biol

Specialty Biology

Date 2018 Apr 26

PMID 29692667

Citations 26

Authors

Masafumi Hayashi

Takamasa Kawaguchi

Gabriela Durcova-Hills

Hiroshi Imai

Affiliations

Soon will be listed here.

Abstract

Background: The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC induction have been established in the mouse. Many attempts are reported to enhance our understanding of PGC development in other mammals, including human.

Methods: Here, original and review articles that have been published on PubMed are reviewed in order to give an overview of the literature that is focused on PGC development, including the specification of in vivo and in vitro in mice, human, porcine, and bovine.

Results: Mammalian PGC development, in vivo and in vitro, have been studied primarily by using the mouse model as a template to study PGC specification in other mammals, including human, porcine, and bovine.

Conclusion: The growing body of published works reveals similarities, as well as differences, in PGC establishment in and between mouse and human.

Citing Articles

Spermatogonial stem cell technologies: applications from human medicine to wildlife conservation†.

Damyanova K, Nixon B, Johnston S, Gambini A, Benitez P, Lord T Biol Reprod. 2024; 111(4):757-779.

PMID: 38993049 PMC: 11473898. DOI: 10.1093/biolre/ioae109.

Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications.

Cerneckis J, Cai H, Shi Y Signal Transduct Target Ther. 2024; 9(1):112.

PMID: 38670977 PMC: 11053163. DOI: 10.1038/s41392-024-01809-0.

Using Embryo Models to Understand the Development and Progression of Embryonic Lineages: A Focus on Primordial Germ Cell Development.

Rodriguez-Polo I, Moris N Cells Tissues Organs. 2024; 213(6):503-522.

PMID: 38479364 PMC: 7616515. DOI: 10.1159/000538275.

CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development.

Bulger E, McDevitt T, Bruneau B Biol Open. 2024; 13(3).

PMID: 38451093 PMC: 10979512. DOI: 10.1242/bio.060323.

Isolation and Purification of Viable PGCs from Mouse Embryos.

De Felici M Methods Mol Biol. 2024; 2770:3-13.

PMID: 38351442 DOI: 10.1007/978-1-0716-3698-5_1.

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