Staphylococcal Enterotoxin C2 Promotes Osteogenesis of Mesenchymal Stem Cells and Accelerates Fracture Healing

Overview

Journal Bone Joint Res

Date 2018 Apr 24

PMID 29682284

Citations 8

Authors

T Wu

J Zhang

B Wang

Y Sun

Y Liu

G Li

Affiliations

Soon will be listed here.

Abstract

Objectives: As one of the heat-stable enterotoxins, C2 (SEC2) is synthesized by , which has been proved to inhibit the growth of tumour cells, and is used as an antitumour agent in cancer immunotherapy. Although SEC2 has been reported to promote osteogenic differentiation of human mesenchymal stem cells (MSCs), the function of SCE2 in animal model remains elusive. The aim of this study was to further elucidate the effect of SCE2 on fracture healing.

Materials And Methods: Rat MSCs were used to test the effects of SEC2 on their proliferation and osteogenic differentiation potentials. A rat femoral fracture model was used to examine the effect of local administration of SEC2 on fracture healing using radiographic analyses, micro-CT analyses, biomechanical testing, and histological analyses.

Results: While SEC2 was found to have no effect on rat MSCs proliferation, it promoted the osteoblast differentiation of rat MSCs. In the rat femoral fracture model, the local administration of SEC2 accelerated fracture healing by increasing fracture callus volumes, bone volume over total volume (BV/TV), and biomechanical recovery. The SEC2 treatment group has superior histological appearance compared with the control group.

Conclusion: These data suggest that local administration of SEC2 may be a novel therapeutic approach to enhancing bone repair such as fracture healing.: T. Wu, J. Zhang, B. Wang, Y. Sun, Y. Liu, G. Li. Staphylococcal enterotoxin C2 promotes osteogenesis of mesenchymal stem cells and accelerates fracture healing. 2018;7:179-186. DOI: 10.1302/2046-3758.72.BJR-2017-0229.R1.

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