Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes

Overview

Journal Front Neuroanat

Date 2018 Apr 24

PMID 29681801

Citations 8

Authors

Qian Wu

Charlie W Zhao

Zhe Long

Bo Xiao

Li Feng

Affiliations

Soon will be listed here.

Abstract

Epilepsy is a paroxysmal neurological disorder characterized by recurrent and unprovoked seizures affecting approximately 50 million people worldwide. Cognitive dysfunction induced by seizures is a severe comorbidity of epilepsy and epilepsy syndromes and reduces patients' quality of life. Seizures, along with accompanying histopathological and pathophysiological changes, are associated with cognitive comorbidities. Advances in imaging technology and computing allow anatomical and topological changes in neural networks to be visualized. Anatomical components including the hippocampus, amygdala, cortex, corpus callosum (CC), cerebellum and white matter (WM) are the fundamental components of seizure- and cognition-related topological networks. Damage to these structures and their substructures results in worsening of epilepsy symptoms and cognitive dysfunction. In this review article, we survey structural, network changes and topological alteration in different regions of the brain and in different epilepsy and epileptic syndromes, and discuss what these changes may mean for cognitive outcomes related to these disease states.

Citing Articles

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References

Hellwig S, Gutmann V, Trimble M, Tebartz van Elst L . Cerebellar volume is linked to cognitive function in temporal lobe epilepsy: a quantitative MRI study. Epilepsy Behav. 2013; 28(2):156-62. DOI: 10.1016/j.yebeh.2013.04.020. View

Keller S, Baker G, Downes J, Roberts N . Quantitative MRI of the prefrontal cortex and executive function in patients with temporal lobe epilepsy. Epilepsy Behav. 2009; 15(2):186-95. DOI: 10.1016/j.yebeh.2009.03.005. View

Magloczky Z . Sprouting in human temporal lobe epilepsy: excitatory pathways and axons of interneurons. Epilepsy Res. 2010; 89(1):52-9. DOI: 10.1016/j.eplepsyres.2010.01.002. View

Kramer M, Kolaczyk E, Kirsch H . Emergent network topology at seizure onset in humans. Epilepsy Res. 2008; 79(2-3):173-86. DOI: 10.1016/j.eplepsyres.2008.02.002. View

Kuroda M, Yokofujita J, Murakami K . An ultrastructural study of the neural circuit between the prefrontal cortex and the mediodorsal nucleus of the thalamus. Prog Neurobiol. 1998; 54(4):417-58. DOI: 10.1016/s0301-0082(97)00070-1. View

Stam C, van Straaten E . The organization of physiological brain networks. Clin Neurophysiol. 2012; 123(6):1067-87. DOI: 10.1016/j.clinph.2012.01.011. View

Li Q, Cao W, Liao X, Chen Z, Yang T, Gong Q . Altered resting state functional network connectivity in children absence epilepsy. J Neurol Sci. 2015; 354(1-2):79-85. DOI: 10.1016/j.jns.2015.04.054. View

Arnold C, Rademaker A, Wolf M, Liu D, Lucas G, Hancock J . Final Results of a 3-Year Literacy-Informed Intervention to Promote Annual Fecal Occult Blood Test Screening. J Community Health. 2016; 41(4):724-31. PMC: 4930386. DOI: 10.1007/s10900-015-0146-6. View

Cho K, Lybrand Z, Ito N, Brulet R, Tafacory F, Zhang L . Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat Commun. 2015; 6:6606. PMC: 4375780. DOI: 10.1038/ncomms7606. View

10.

Hermann B, Seidenberg M, Jones J . The neurobehavioural comorbidities of epilepsy: can a natural history be developed?. Lancet Neurol. 2008; 7(2):151-60. DOI: 10.1016/S1474-4422(08)70018-8. View

11.

Lawson J, Cook M, Vogrin S, Litewka L, Strong D, Bleasel A . Clinical, EEG, and quantitative MRI differences in pediatric frontal and temporal lobe epilepsy. Neurology. 2002; 58(5):723-9. DOI: 10.1212/wnl.58.5.723. View

12.

Mancuso J, Cheng J, Yin Z, Gilliam J, Xia X, Li X . Integration of multiscale dendritic spine structure and function data into systems biology models. Front Neuroanat. 2014; 8:130. PMC: 4228840. DOI: 10.3389/fnana.2014.00130. View

13.

Wandschneider B, Thompson P, Vollmar C, Koepp M . Frontal lobe function and structure in juvenile myoclonic epilepsy: a comprehensive review of neuropsychological and imaging data. Epilepsia. 2012; 53(12):2091-8. DOI: 10.1111/epi.12003. View

14.

Berkovic S, McIntosh A, Kalnins R, Jackson G, Fabinyi G, Brazenor G . Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis. Neurology. 1995; 45(7):1358-63. DOI: 10.1212/wnl.45.7.1358. View

15.

Wang Z, Dai Z, Gong G, Zhou C, He Y . Understanding structural-functional relationships in the human brain: a large-scale network perspective. Neuroscientist. 2014; 21(3):290-305. DOI: 10.1177/1073858414537560. View

16.

Thom M . Hippocampal sclerosis: progress since Sommer. Brain Pathol. 2008; 19(4):565-72. PMC: 8094764. DOI: 10.1111/j.1750-3639.2008.00201.x. View

17.

Alvarez P, Simao F, Hemb M, Leal Xavier L, Nunes M . Effects of undernourishment, recurrent seizures and enriched environment during early life in hippocampal morphology. Int J Dev Neurosci. 2013; 33:81-7. DOI: 10.1016/j.ijdevneu.2013.12.004. View

18.

Wang Z, Tian C, Dhamala M, Liu Z . A small change in neuronal network topology can induce explosive synchronization transition and activity propagation in the entire network. Sci Rep. 2017; 7(1):561. PMC: 5428839. DOI: 10.1038/s41598-017-00697-5. View

19.

Horstmann M, Bialonski S, Noennig N, Mai H, Prusseit J, Wellmer J . State dependent properties of epileptic brain networks: comparative graph-theoretical analyses of simultaneously recorded EEG and MEG. Clin Neurophysiol. 2010; 121(2):172-85. DOI: 10.1016/j.clinph.2009.10.013. View

20.

Bandopadhyay R, Liu J, Sisodiya S, Thom M . A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia. Neuropathol Appl Neurobiol. 2013; 40(2):177-90. PMC: 4282449. DOI: 10.1111/nan.12087. View