Integration of Multiscale Dendritic Spine Structure and Function Data into Systems Biology Models

Overview

Journal Front Neuroanat

Date 2014 Nov 28

PMID 25429262

Citations 9

Authors

James J Mancuso

Jie Cheng

Zheng Yin

Jared C Gilliam

Xiaofeng Xia

Xuping Li

Stephen T C Wong

Affiliations

Soon will be listed here.

Abstract

Comprising 10(11) neurons with 10(14) synaptic connections the human brain is the ultimate systems biology puzzle. An increasing body of evidence highlights the observation that changes in brain function, both normal and pathological, consistently correlate with dynamic changes in neuronal anatomy. Anatomical changes occur on a full range of scales from the trafficking of individual proteins, to alterations in synaptic morphology both individually and on a systems level, to reductions in long distance connectivity and brain volume. The major sites of contact for synapsing neurons are dendritic spines, which provide an excellent metric for the number and strength of signaling connections between elements of functional neuronal circuits. A comprehensive model of anatomical changes and their functional consequences would be a holy grail for the field of systems neuroscience but its realization appears far on the horizon. Various imaging technologies have advanced to allow for multi-scale visualization of brain plasticity and pathology, but computational analysis of the big data sets involved forms the bottleneck toward the creation of multiscale models of brain structure and function. While a full accounting of techniques and progress toward a comprehensive model of brain anatomy and function is beyond the scope of this or any other single paper, this review serves to highlight the opportunities for analysis of neuronal spine anatomy and function provided by new imaging technologies and the high-throughput application of older technologies while surveying the strengths and weaknesses of currently available computational analytical tools and room for future improvement.

Citing Articles

Morphological Features of Human Dendritic Spines.

Renner J, Rasia-Filho A Adv Neurobiol. 2023; 34:367-496.

PMID: 37962801 DOI: 10.1007/978-3-031-36159-3_9.

Introduction: What Are Dendritic Spines?.

Rasia-Filho A, Calcagnotto M, von Bohlen Und Halbach O Adv Neurobiol. 2023; 34:1-68.

PMID: 37962793 DOI: 10.1007/978-3-031-36159-3_1.

Unraveling Brain Microcircuits, Dendritic Spines, and Synaptic Processing Using Multiple Complementary Approaches.

Rasia-Filho A Front Physiol. 2022; 13:831568.

PMID: 35295578 PMC: 8918670. DOI: 10.3389/fphys.2022.831568.

Quantification of Dendritic Spines Remodeling under Physiological Stimuli and in Pathological Conditions.

Baczynska E, Pels K, Basu S, Wlodarczyk J, Ruszczycki B Int J Mol Sci. 2021; 22(8).

PMID: 33919977 PMC: 8070910. DOI: 10.3390/ijms22084053.

Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination.

Chen H, Tian J, Guo L, Du H Sci Rep. 2020; 10(1):17589.

PMID: 33067541 PMC: 7568535. DOI: 10.1038/s41598-020-74613-9.

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