Human Adult Neurogenesis: Evidence and Remaining Questions

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2018 Apr 24

PMID 29681514

Citations 369

Authors

Gerd Kempermann

Fred H Gage

Ludwig Aigner

Hongjun Song

Maurice A Curtis

Sandrine Thuret

H Georg Kuhn

Sebastian Jessberger

Paul W Frankland

Heather A Cameron

Elizabeth Gould

Rene Hen

D Nora Abrous

Nicolas Toni

Alejandro F Schinder

Xinyu Zhao

Paul J Lucassen

Jonas Frisen

Affiliations

Soon will be listed here.

Abstract

Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

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