The Hypothalamo-neurohypophysial System in Streptozotocin-diabetic Rats: Ultrastructural and Immunocytochemical Evidence for Alterations of Oxytocin- and Vasopressin-containing Neuronal Profiles

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1988 Jan 1

PMID 2966536

Citations 1

Authors

A Loesch

J Lincoln

G Burnstock

Affiliations

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Abstract

The hypothalamic paraventricular and supraoptic nuclei and the neurohypophysis of rats were investigated 8 weeks after streptozotocin (STZ)-induction of type 1 diabetes. Vasopressin (VP)- and oxytocin (OT)-containing neuronal profiles were examined using the pre-embedding peroxidase-antiperoxidase technique for electron microscopy. Ultrastructural alterations were observed in the somata, dendrites and axons of VP- and OT-labelled profiles. There was no evidence, however, for alterations in the synapses associated with VP- or OT-labelled somata, dendrites and axons. The results indicate that both VP- and OT-containing neuronal profiles are involved in the ultrastructural reorganisation of the hypothalamo-neurohypophysial complex during diabetic conditions. Depletion of VP- and OT-containing axon profiles in the neurohypophysis may suggest increased release of both neurohypophysial hormones in STZ-induced diabetes.

Citing Articles

State of the vasopressin-, oxytocin-, and corticoliberin-synthesizing structures of the hypothalamus in experimental diabetes in rats of both sexes.

Kolesnik YuM , Orestenko YuN , Abramov A Neurosci Behav Physiol. 1994; 24(2):163-6.

PMID: 8065553 DOI: 10.1007/BF02355674.

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