Diagnostic Utility of Cardiac Troponin I in Cats with Hypertrophic Cardiomyopathy

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2018 Apr 17

PMID 29660794

Citations 17

Authors

Yasutomo Hori

Masayuki Iguchi

Yasuhiro Heishima

Yohei Yamashita

Kensuke Nakamura

Atsushi Hirakawa

Akihito Kitade

Toshiki Ibaragi

Michio Katagi

Tamotsu Sawada

Masashi Yuki

Nobuyuki Kanno

Haruki Inaba

Noriko Isayama

Hideyuki Onodera

Naoki Iwasa

Mikio Kino

Mikihiro Narukawa

Syuhei Uchida

Affiliations

Soon will be listed here.

Abstract

Background: Cardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats.

Objective: To measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM.

Animals: Clinically healthy cats (n = 88) and cats with HCM (n = 93).

Methods: Multicenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography. Plasma cTnI concentrations were analyzed by a commercial laboratory. Receiver-operating characteristic curve analysis was used to evaluate the accuracy of plasma cTnI concentrations to detect HCM.

Results: The median cTnI concentration was 0.027 ng/mL (interquartile range, 0.012-0.048 ng/mL) in healthy cats. Concentrations were significantly higher in diseased cats than in healthy controls, and concentrations were significantly higher in cats with heart failure than in asymptomatic cats. A plasma cTnI concentration of 0.163 ng/mL had a sensitivity of 62.0% and specificity of 100% when used to distinguish normal cats from asymptomatic HCM cats without left atrial dilatation. A cutoff of 0.234 ng/mL had high sensitivity (95.0%) and specificity (77.8%) for assessing heart failure. The areas under the receiver-operating characteristic curves were 0.85 and 0.93, respectively.

Conclusions And Clinical Importance: Increased cTnI concentrations reflect the severity of HCM. If other causes of cardiac injury are ruled out, plasma cTnI concentration may be useful for predicting the severity of HCM in cats.

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