T Cell Growth and Differentiation Induced by Interleukin-HP1/IL-6, the Murine Hybridoma/plasmacytoma Growth Factor

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1988 Apr 1

PMID 2965738

Citations 61

Authors

C Uyttenhove

P G Coulie

J Van Snick

Affiliations

Soon will be listed here.

Abstract

Interleukin-HP1 (HP1)/IL-6 is a 25-30-kD protein produced by macrophages, fibroblasts, and certain T cell lines. It was originally identified as a mouse growth factor for B cell hybridomas and plasmacytomas, and was recently shown to stimulate growth and differentiation of normal B cells. Here we demonstrate that, in the presence of lectins or anti-T cell receptor antibodies, HP1/IL-6 has a growth factor activity equivalent to that of IL-2 for mature thymic and peripheral T cells of both the L3T4+ and Lyt-2+ subsets. Contrary to IL-2 and IL-4, HP1/IL-6 was, however, not capable of supporting the growth of established T cell lines. In addition to its effects on T cell proliferation, HP1/IL-6 also enhanced the differentiation of mouse cytolytic T cell precursors in primary allogeneic mixed lymphocyte cultures. Fractionation of responding cell populations indicated that HP1/IL-6 was capable of restoring the response of accessory cell-depleted T cells to Con A. This observation suggests that the production of HP1/IL-6 by macrophages could, at least partly, explain their role in polyclonal T cell activation.

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References

OHara J, Paul W . Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature. 1985; 315(6017):333-6. DOI: 10.1038/315333a0. View

Bazin H, Xhurdebise L, Burtonboy G, Lebacq A, De Clercq L, Cormont F . Rat monoclonal antibodies. I. Rapid purification from in vitro culture supernatants. J Immunol Methods. 1984; 66(2):261-9. DOI: 10.1016/0022-1759(84)90337-5. View

Haegeman G, Content J, Volckaert G, Derynck R, Tavernier J, Fiers W . Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. Eur J Biochem. 1986; 159(3):625-32. DOI: 10.1111/j.1432-1033.1986.tb09931.x. View

Zilberstein A, Ruggieri R, Korn J, Revel M . Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J. 1986; 5(10):2529-37. PMC: 1167149. DOI: 10.1002/j.1460-2075.1986.tb04531.x. View

Van Snick J, Cayphas S, Vink A, Uyttenhove C, Coulie P, Rubira M . Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas. Proc Natl Acad Sci U S A. 1986; 83(24):9679-83. PMC: 387204. DOI: 10.1073/pnas.83.24.9679. View

Garman R, Raulet D . Characterization of a novel murine T cell-activating factor. J Immunol. 1987; 138(4):1121-9. View

Van Snick J, Vink A, Cayphas S, Uyttenhove C . Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas. J Exp Med. 1987; 165(3):641-9. PMC: 2188283. DOI: 10.1084/jem.165.3.641. View

Van Damme J, Opdenakker G, Simpson R, Rubira M, Cayphas S, Vink A . Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med. 1987; 165(3):914-9. PMC: 2188297. DOI: 10.1084/jem.165.3.914. View

Leo O, Foo M, Sachs D, Samelson L, Bluestone J . Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A. 1987; 84(5):1374-8. PMC: 304432. DOI: 10.1073/pnas.84.5.1374. View

10.

Hardt C, Sato N, Wagner H . Functional and biochemical characteristics of a murine interleukin 2 receptor-inducing factor. Eur J Immunol. 1987; 17(2):209-16. DOI: 10.1002/eji.1830170210. View

11.

Nordan R, Pumphrey J, Rudikoff S . Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1. J Immunol. 1987; 139(3):813-7. View

12.

Poupart P, Vandenabeele P, Cayphas S, Van Snick J, Haegeman G, Kruys V . B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF). EMBO J. 1987; 6(5):1219-24. PMC: 553922. DOI: 10.1002/j.1460-2075.1987.tb02357.x. View

13.

Coulie P, Cayphas S, Vink A, Uyttenhove C, Van Snick J . Interleukin-HP1-related hybridoma and plasmacytoma growth factors induced by lipopolysaccharide in vivo. Eur J Immunol. 1987; 17(8):1217-20. DOI: 10.1002/eji.1830170821. View

14.

Taga T, Kawanishi Y, Hardy R, Hirano T, Kishimoto T . Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med. 1987; 166(4):967-81. PMC: 2188724. DOI: 10.1084/jem.166.4.967. View

15.

Cayphas S, Van Damme J, Vink A, Simpson R, Billiau A, Van Snick J . Identification of an interleukin HP1-like plasmacytoma growth factor produced by L cells in response to viral infection. J Immunol. 1987; 139(9):2965-9. View

16.

Gauldie J, Richards C, Harnish D, Lansdorp P, Baumann H . Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci U S A. 1987; 84(20):7251-5. PMC: 299269. DOI: 10.1073/pnas.84.20.7251. View

17.

Garman R, Jacobs K, Clark S, Raulet D . B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci U S A. 1987; 84(21):7629-33. PMC: 299353. DOI: 10.1073/pnas.84.21.7629. View

18.

Brakenhoff J, de Groot E, Evers R, Pannekoek H, Aarden L . Molecular cloning and expression of hybridoma growth factor in Escherichia coli. J Immunol. 1987; 139(12):4116-21. View

19.

Van Snick J, Cayphas S, Szikora J, Renauld J, Van Roost E, Boon T . cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. Eur J Immunol. 1988; 18(2):193-7. DOI: 10.1002/eji.1830180202. View

20.

Mannel D, Mizel S, DIAMANTSTEIN T, Falk W . Induction of interleukin 2 responsiveness in thymocytes by synergistic action of interleukin 1 and interleukin 2. J Immunol. 1985; 134(5):3108-10. View