Full-Genome Characterization and Genetic Evolution of West African Isolates of Bagaza Virus

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2018 Apr 14

PMID 29652824

Citations 4

Authors

Martin Faye

Oumar Faye

Moussa Moise Diagne

Gamou Fall

Manfred Weidmann

Mbacke Sembene

Amadou Alpha Sall

Ousmane Faye

Affiliations

Soon will be listed here.

Abstract

Bagaza virus is a mosquito-borne flavivirus, first isolated in 1966 in Central African Republic. It has currently been identified in mosquito pools collected in the field in West and Central Africa. Emergence in wild birds in Europe and serological evidence in encephalitis patients in India raise questions on its genetic evolution and the diversity of isolates circulating in Africa. To better understand genetic diversity and evolution of Bagaza virus, we describe the full-genome characterization of 11 West African isolates, sampled from 1988 to 2014. Parameters such as genetic distances, N-glycosylation patterns, recombination events, selective pressures, and its codon adaptation to human genes are assessed. Our study is noteworthy for the observation of N-glycosylation and recombination in Bagaza virus and provides insight into its Indian origin from the 13th century. Interestingly, evidence of Bagaza virus codon adaptation to human house-keeping genes is also observed to be higher than those of other flaviviruses well known in human infections. Genetic variations on genome of West African Bagaza virus could play an important role in generating diversity and may promote Bagaza virus adaptation to other vertebrates and become an important threat in human health.

Citing Articles

Establishment of a New Real-Time Molecular Assay for the Detection of Babanki Virus in Africa.

Faye M, Ban M, Top F, Ndiaye E, Thiaw F, Fall G Viruses. 2025; 16(12.

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Emergence of Two Different Genotypes of Bagaza Virus (BAGV) Affecting Red-Legged Partridges in Spain, in 2019 and 2021.

Aguilera-Sepulveda P, Gomez-Martin B, Aguero M, Jimenez-Clavero M, Fernandez-Pinero J Pathogens. 2024; 13(9).

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Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations.

Ullah S, Ullah F, Rahman W, Ullah A, Haider S, Yueguang C PLoS One. 2024; 19(8):e0307902.

PMID: 39116118 PMC: 11309477. DOI: 10.1371/journal.pone.0307902.

Genome Characterization and Spaciotemporal Dispersal Analysis of Bagaza Virus Detected in Portugal, 2021.

Falcao M, Barros M, Duarte M, Santos F, Fagulha T, Henriques M Pathogens. 2023; 12(2).

PMID: 36839422 PMC: 9962176. DOI: 10.3390/pathogens12020150.

Phylogenetic Characterisation of the Full Genome of a Bagaza Virus Isolate from Bird Fatalities in South Africa.

Mendes A, Lentsoane O, Allam M, Khumalo Z, Ismail A, Coetzer J Viruses. 2022; 14(7).

PMID: 35891456 PMC: 9324014. DOI: 10.3390/v14071476.

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