Epigenome-Wide Association Study of Dietary Fiber Intake in African American Adolescents

Overview

Journal Mol Nutr Food Res

Specialty Nutritional Sciences

Date 2018 Apr 13

PMID 29644791

Citations 6

Authors

Li Chen

Yanbin Dong

Xiaoling Wang

Guang Hao

Ying Huang

Bernard Gutin

Haidong Zhu

Affiliations

Soon will be listed here.

Abstract

Scope: Low fiber intake is associated with increased risk for cardiovascular disease (CVD) and cancer. However, the underlying mechanisms are not well understood. Two hypotheses are tested: 1) dietary fiber would be associated with DNA methylation levels; 2) those DNA methylation changes would be associated with visceral adiposity and inflammation. Also the possibility that the associations between fiber and DNA methylation levels might be confounded with folic acid intake as sensitivity analysis are explored.

Methods And Results: An epigenome-wide association study is conducted using Illumina 450K Bead-Chip on leukocyte DNA in 284 African American adolescents. Linear regression is performed to identify differentially methylated CpG sites associated with fiber. The methylation levels of 3 CpG sites (cg15200711, cg19462022, and cg07035602) in LPCAT1 and RASA3 genes are associated with fiber (false discovery rate [FDR] < 0.05) after adjustment for covariates including folic acid. The methylation levels of cg07035602 and cg19462022 are also associated with visceral adiposity and inflammation.

Conclusions: The data show that DNA methylation levels at LPCAT1 and RASA3 genes are associated with dietary fiber intake as well as with adiposity and inflammation. Future studies are warranted to determine whether epigenetic regulation may underlie the beneficial effects of fiber intake on adiposity and inflammation.

Citing Articles

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Essential Nutrients, Added Sugar Intake, and Epigenetic Age in Midlife Black and White Women: NIMHD Social Epigenomics Program.

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Diet Quality and Epigenetic Aging in the Women's Health Initiative.

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Do W, Whitsel E, Costeira R, Masachs O, Le Roy C, Bell J Int J Epidemiol. 2020; 50(2):675-684.

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