VEGF Levels in Plasma in Relation to Metabolic Control, Inflammation, and Microvascular Complications in Type-2 Diabetes: A Cohort Study

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2018 Apr 12

PMID 29642210

Citations 35

Authors

Qin Zhang

Wen Fang

Li Ma

Zhao-Di Wang

Yun-Mei Yang

Yuan-Qiang Lu

Affiliations

Soon will be listed here.

Abstract

The vascular endothelial growth factor (VEGF) level in human circulation may reflect the severity of endothelial dysfunction in patients with diabetes mellitus, which leads to diabetic microvascular complications.We determined plasma VEGF levels as well as metabolic control and inflammatory factors in 26 healthy subjects and 52 type-2 diabetes mellitus (T2DM) patients with or without diabetic microvascular complications. Pearson correlation coefficient was used to evaluate the associations among those indices.The results showed that VEGF levels in plasma were positively correlated with fasting blood glucose level, glycosylated hemoglobin (HbA1c) level, type 1 helper T cell (Th1) percentage, and Th1/Th2 ratio, while they were negatively correlated with regulatory T cell percentage. Multiple linear regression analysis showed that HbA1c and Th1/Th2 ratio were the independent predictors of VEGF levels in T2DM patients.Thus, in T2DM patients with poor glycemic control as well as an elevated Th1/Th2 cell ratio, more VEGF might be released.

Citing Articles

Vascular endothelial growth factor as a potential biomarker in systemic sclerosis: a systematic review and meta-analysis.

Zinellu A, Mangoni A Front Immunol. 2024; 15:1442913.

PMID: 39669565 PMC: 11634811. DOI: 10.3389/fimmu.2024.1442913.

Machine learning approaches and genetic determinants that influence the development of type 2 diabetes mellitus: a genetic association study in Brazilian patients.

Santos K, Assuncao L, Santos R, Reis A Braz J Med Biol Res. 2024; 57:e13957.

PMID: 39630807 PMC: 11653484. DOI: 10.1590/1414-431X2024e13957.

Luteinizing hormone is independently associated with high-sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross-sectional study.

Wang Y, Li Y, Liu C, Wang Y, Li Y J Diabetes. 2024; 16(10):e70005.

PMID: 39436203 PMC: 11494916. DOI: 10.1111/1753-0407.70005.

Differential expression of cardiometabolic and inflammation markers and signaling pathways between overweight/obese Qatari adults with high and low plasma salivary α-amylase activity.

Khalifa O, Al-Akl N, Arredouani A Front Endocrinol (Lausanne). 2024; 15:1421358.

PMID: 39411310 PMC: 11473332. DOI: 10.3389/fendo.2024.1421358.

Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy.

Ratan Y, Rajput A, Pareek A, Pareek A, Kaur R, Sonia S Biomedicines. 2024; 12(7).

PMID: 39061964 PMC: 11273858. DOI: 10.3390/biomedicines12071390.

References

Tufro A, Veron D . VEGF and podocytes in diabetic nephropathy. Semin Nephrol. 2012; 32(4):385-93. PMC: 3438453. DOI: 10.1016/j.semnephrol.2012.06.010. View

. Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991; 98(5 Suppl):807-22. View

Gunsilius E, Petzer A, Stockhammer G, Nussbaumer W, Schumacher P, Clausen J . Thrombocytes are the major source for soluble vascular endothelial growth factor in peripheral blood. Oncology. 2000; 58(2):169-74. DOI: 10.1159/000012095. View

Chen J, Gu Z, Wu M, Yang Y, Zhang J, Ou J . C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways. Stem Cell Res Ther. 2016; 7(1):114. PMC: 4986362. DOI: 10.1186/s13287-016-0377-1. View

Mahdy R, Nada W, Hadhoud K, El-Tarhony S . The role of vascular endothelial growth factor in the progression of diabetic vascular complications. Eye (Lond). 2010; 24(10):1576-84. DOI: 10.1038/eye.2010.86. View

Schlingemann R, van Noorden C, Diekman M, Tiller A, Meijers J, Koolwijk P . VEGF levels in plasma in relation to platelet activation, glycemic control, and microvascular complications in type 1 diabetes. Diabetes Care. 2013; 36(6):1629-34. PMC: 3661842. DOI: 10.2337/dc12-1951. View

Asselbergs F, de Boer R, Diercks G, Langeveld B, Tio R, de Jong P . Vascular endothelial growth factor: the link between cardiovascular risk factors and microalbuminuria?. Int J Cardiol. 2004; 93(2-3):211-5. DOI: 10.1016/j.ijcard.2003.04.001. View

Chiarelli F, Spagnoli A, Basciani F, Tumini S, Mezzetti A, Cipollone F . Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complications. Diabet Med. 2000; 17(9):650-6. DOI: 10.1046/j.1464-5491.2000.00350.x. View

Hooshmand B, Polvikoski T, Kivipelto M, Tanskanen M, Myllykangas L, Erkinjuntti T . Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study. Brain. 2013; 136(Pt 9):2707-16. PMC: 3754457. DOI: 10.1093/brain/awt206. View

10.

Brychtova S, Bezdekova M, Brychta T, Tichy M . The role of vascular endothelial growth factors and their receptors in malignant melanomas. Neoplasma. 2008; 55(4):273-9. View

11.

Lu Y, Gu L, Zhang Q, Jiang J, Mou H . Hypertonic saline resuscitation contributes to early accumulation of circulating myeloid-derived suppressor cells in a rat model of hemorrhagic shock. Chin Med J (Engl). 2013; 126(7):1317-22. View

12.

Ma Y, Zhang Y, Zhao T, Jiang Y . Vascular endothelial growth factor in plasma and vitreous fluid of patients with proliferative diabetic retinopathy patients after intravitreal injection of bevacizumab. Am J Ophthalmol. 2011; 153(2):307-313.e2. DOI: 10.1016/j.ajo.2011.08.006. View

13.

Salven P, Teerenhovi L, Joensuu H . A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma. Blood. 1997; 90(8):3167-72. View

14.

Ruszkowska-Ciastek B, Sokup A, Socha M, Ruprecht Z, Halas L, Goralczyk B . A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus. J Zhejiang Univ Sci B. 2014; 15(6):575-81. PMC: 4116851. DOI: 10.1631/jzus.B1400024. View

15.

Nagai Y, Tasaki H, Takatsu H, Nihei S, Yamashita K, Toyokawa T . Homocysteine inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun. 2001; 281(3):726-31. DOI: 10.1006/bbrc.2001.4400. View

16.

Oosterbaan A, Steegers E, Ursem N . The effects of homocysteine and folic acid on angiogenesis and VEGF expression during chicken vascular development. Microvasc Res. 2011; 83(2):98-104. DOI: 10.1016/j.mvr.2011.11.001. View

17.

DeFronzo R, Ferrannini E, Groop L, Henry R, Herman W, Holst J . Type 2 diabetes mellitus. Nat Rev Dis Primers. 2016; 1:15019. DOI: 10.1038/nrdp.2015.19. View

18.

Veron D, Bertuccio C, Marlier A, Reidy K, Garcia A, Jimenez J . Podocyte vascular endothelial growth factor (Vegf₁₆₄) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Diabetologia. 2011; 54(5):1227-41. PMC: 3397150. DOI: 10.1007/s00125-010-2034-z. View

19.

Guo L, Jiang F, Tang Y, Si M, Jiao X . The association of serum vascular endothelial growth factor and ferritin in diabetic microvascular disease. Diabetes Technol Ther. 2013; 16(4):224-34. PMC: 3952528. DOI: 10.1089/dia.2013.0181. View

20.

Zhang Q, Lu Y, Jiang J, Gu L, Mou H . Early changes of CD4⁺CD25⁺Foxp3⁺ regulatory T cells and Th1/Th2, Tc1/Tc2 profiles in the peripheral blood of rats with controlled hemorrhagic shock and no fluid resuscitation. Chin Med J (Engl). 2012; 125(12):2163-7. View