Antipsoriatic Effects of Wannachawee Recipe on Imiquimod-Induced Psoriasis-Like Dermatitis in BALB/c Mice

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2018 Apr 6

PMID 29619073

Citations 19

Authors

Mingkwan Na Takuathung

Ariyaphong Wongnoppavich

Ampai Panthong

Parirat Khonsung

Natthakarn Chiranthanut

Noppamas Soonthornchareonnon

Seewaboon Sireeratawong

Affiliations

Soon will be listed here.

Abstract

Psoriasis is a common immune-mediated chronic inflammatory skin disease characterized by thick and erythema raised plaques with adherent silvery scales. T-cells are activated via the IL-23/Th17 axis which is involved in psoriasis pathogenesis. Conventional treatments of psoriasis have adverse events that influence patients' adherence. Wannachawee Recipe (WCR) is Thai traditional medicine that is known to be effective for psoriasis patients; however, preclinical evidence is still lacking. This study investigated the therapeutic potential of WCR on antiproliferant activity using imiquimod- (IMQ-) induced psoriasis-like dermatitis in a mouse model. Psoriasis-like dermatitis was induced on the shaved dorsal skin and right ear pinna of BALB/c mice by topical application of IMQ for 15 consecutive days after which WCR was administered to the mice by oral gavage for 10 days. Phenotypical observations, histopathological examinations, and ELISA of skin and blood samples were conducted. WCR significantly ameliorated development of IMQ-induced psoriasis-like dermatitis and reduced levels of Th17 cytokines (IL-17A, IL-22, and IL-23) in both serum and dorsal skin. Histopathological findings showed a decrease in epidermal thickness and inflammatory T-cell infiltration in the WCR-treated groups. The WCR has pharmacological actions which regulate Th17 related cytokines suggesting that it is a potential alternative therapeutic strategy for psoriasis.

Citing Articles

A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions.

Nourbakhsh F, Mousavi S, Rahmanian-Devin P, Baradaran Rahimi V, Rakhshandeh H, Askari V Avicenna J Phytomed. 2023; 13(4):412-428.

PMID: 37663384 PMC: 10474920. DOI: 10.22038/AJP.2023.21828.

Antiproliferative and Anti-Inflammatory Activities of Deprungsith Formulation and Its Bioactive Compounds Against Mild Psoriasis and Potential of Metabolic Herb-Drug Interactions.

Na-Bangchang K, Teerachaisakul M, Muhamad P, Kasemnitichok Y, Sangnarong N, Boonprasert K J Evid Based Integr Med. 2023; 28:2515690X231191101.

PMID: 37553989 PMC: 10413907. DOI: 10.1177/2515690X231191101.

Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis.

Vanden Heuvel J, Zhou S, Patel A, Kamerow H, Baran P, Ford J Biomed Res Int. 2023; 2023:4878774.

PMID: 37469991 PMC: 10353900. DOI: 10.1155/2023/4878774.

Augmented Transdermal Delivery of Curcumin for the Effective Management of Plaque Psoriasis - Design, Formulation, Characterisation, and In Vivo Studies.

Kumar B, Sahoo P AAPS PharmSciTech. 2023; 24(5):134.

PMID: 37291356 DOI: 10.1208/s12249-023-02595-8.

Efficacy of stem cell secretome loaded in hyaluronate sponge for topical treatment of psoriasis.

Carrillo D, Edwards N, Arancibia-Altamirano D, Otarola F, Villarroel C, Prieto C Bioeng Transl Med. 2023; 8(2):e10443.

PMID: 36925706 PMC: 10013801. DOI: 10.1002/btm2.10443.

References

Disayavanish C, Disayavanish P . Introduction of the treatment method of Thai traditional medicine: its validity and future perspectives. Psychiatry Clin Neurosci. 1999; 52 Suppl:S334-7. DOI: 10.1111/j.1440-1819.1998.tb03261.x. View

Chan J, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S . IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006; 203(12):2577-87. PMC: 2118145. DOI: 10.1084/jem.20060244. View

Takuathung M, Wongnoppavich A, Pitchakarn P, Panthong A, Khonsung P, Chiranthanut N . Effects of Wannachawee Recipe with Antipsoriatic Activity on Suppressing Inflammatory Cytokine Production in HaCaT Human Keratinocytes. Evid Based Complement Alternat Med. 2017; 2017:5906539. PMC: 5576424. DOI: 10.1155/2017/5906539. View

Wang G, Liu Y . Traditional Chinese medicine is effective and safe in the treatment of psoriasis. Int J Dermatol. 2004; 43(7):552. DOI: 10.1111/j.1365-4632.2004.02181.x. View

Menter A, Korman N, Elmets C, Feldman S, Gelfand J, Gordon K . Guidelines of care for the management of psoriasis and psoriatic arthritis: section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents. J Am Acad Dermatol. 2009; 61(3):451-85. DOI: 10.1016/j.jaad.2009.03.027. View

Boniface K, Blom B, Liu Y, De Waal Malefyt R . From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev. 2009; 226:132-46. PMC: 3660846. DOI: 10.1111/j.1600-065X.2008.00714.x. View

Corson T, Crews C . Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007; 130(5):769-74. PMC: 2507744. DOI: 10.1016/j.cell.2007.08.021. View

Augustin M, Holland B, Dartsch D, Langenbruch A, Radtke M . Adherence in the treatment of psoriasis: a systematic review. Dermatology. 2011; 222(4):363-74. DOI: 10.1159/000329026. View

Elmore S . Enhanced histopathology of the spleen. Toxicol Pathol. 2006; 34(5):648-55. PMC: 1828535. DOI: 10.1080/01926230600865523. View

10.

Winterfield L, Cather J, Cather J, Menter A . Changing paradigms in dermatology: nuclear hormone receptors. Clin Dermatol. 2003; 21(5):447-54. DOI: 10.1016/j.clindermatol.2003.08.011. View

11.

Kim C, Kim J, Lee A . Therapeutic and immunomodulatory effects of glucosamine in combination with low-dose cyclosporine a in a murine model of imiquimod-induced psoriasis. Eur J Pharmacol. 2015; 756:43-51. DOI: 10.1016/j.ejphar.2015.03.010. View

12.

Vijayalakshmi A, Ravichandiran V, Malarkodi V, Nirmala S, Jayakumari S . Screening of flavonoid "quercetin" from the rhizome of Smilax china Linn. for anti-psoriatic activity. Asian Pac J Trop Biomed. 2013; 2(4):269-75. PMC: 3609293. DOI: 10.1016/S2221-1691(12)60021-5. View

13.

Korn T, Bettelli E, Oukka M, Kuchroo V . IL-17 and Th17 Cells. Annu Rev Immunol. 2009; 27:485-517. DOI: 10.1146/annurev.immunol.021908.132710. View

14.

Flutter B, Nestle F . TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis. Eur J Immunol. 2013; 43(12):3138-46. DOI: 10.1002/eji.201343801. View

15.

Christensen S, Johnson T, Markel P, Clark V, Fulker D, Corley R . Quantitative trait locus analyses of sleep-times induced by sedative-hypnotics in LSXSS recombinant inbred strains of mice. Alcohol Clin Exp Res. 1996; 20(3):543-50. DOI: 10.1111/j.1530-0277.1996.tb01090.x. View

16.

Cai Y, Fleming C, Yan J . New insights of T cells in the pathogenesis of psoriasis. Cell Mol Immunol. 2012; 9(4):302-9. PMC: 4132586. DOI: 10.1038/cmi.2012.15. View

17.

Dogra S, Yadav S . Acitretin in psoriasis: an evolving scenario. Int J Dermatol. 2014; 53(5):525-38. DOI: 10.1111/ijd.12365. View

18.

Lee E, Trepicchio W, Oestreicher J, Pittman D, Wang F, Chamian F . Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med. 2004; 199(1):125-30. PMC: 1887731. DOI: 10.1084/jem.20030451. View

19.

Saelee C, Thongrakard V, Tencomnao T . Effects of Thai medicinal herb extracts with anti-psoriatic activity on the expression on NF-κB signaling biomarkers in HaCaT keratinocytes. Molecules. 2011; 16(5):3908-32. PMC: 6263342. DOI: 10.3390/molecules16053908. View

20.

Gotoh A, Sakaeda T, Kimura T, Shirakawa T, Wada Y, Wada A . Antiproliferative activity of Rhinacanthus nasutus (L.) Kurz extracts and the active moiety, Rhinacanthin C. Biol Pharm Bull. 2004; 27(7):1070-4. DOI: 10.1248/bpb.27.1070. View