From Interleukin-23 to T-helper 17 Cells: Human T-helper Cell Differentiation Revisited

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2009 Jan 24

PMID 19161421

Citations 80

Authors

Katia Boniface

Bianca Blom

Yong-Jun Liu

Rene De Waal Malefyt

Affiliations

Soon will be listed here.

Abstract

Protracted inflammation leading to dysregulation of effector T-cell responses represents a common feature of a wide range of autoimmune diseases. The interleukin-12 (IL-12)/T-helper 1 (Th1) pathway was thought to be responsible for the pathogenesis of multiple chronic inflammatory diseases, including psoriasis, inflammatory bowel disease, arthritis, or multiple sclerosis, mainly through their production of interferon-gamma and its effects on macrophage activation and chemokine production. However, this initial concept of T-cell-mediated chronic inflammation required an adjustment with the discovery of an IL-12-related cytokine, designated IL-23. IL-23 was rapidly recognized for its involvement in the establishment of chronic inflammation and in the development of a Th cell subset producing IL-17, designated Th17, which is distinct from the previously reported Th1 and Th2 populations. This review aims to describe the characterization of IL-23 and its receptor, its biological activities, as well as its involvement in the development of human Th17 cells and autoimmunity.

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