The Function of Notch1 Intracellular Domain in the Differentiation of Gastric Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2018 Apr 5

PMID 29616098

Citations 6

Authors

Sunkuan Hu

Qiuxiang Chen

Tiesu Lin

Wandong Hong

Wenzhi Wu

Ming Wu

Xiaojing Du

Rong Jin

Affiliations

Soon will be listed here.

Abstract

Due to the complex function of the Notch signal pathway in gastric cancer (GC), the association between Notch homolog 1 (Notch1) intracellular domain (NICD) and differentiation of GC remains unknown. The present study aimed to investigate the potential association between NICD and GC differentiation, and demonstrated that poorly differentiated GC expressed increased NICD levels compared with well differentiated GC. A γ-secretase inhibitor inhibited the growth of AGS cells through downregulating NICD level. Additional data suggested that a COX-2 inhibitor caused a marked reduction of NICD level in comparison with a control group treated with dimethyl sulfoxide. Combined administration of γ-secretase and COX-2 inhibitor produced a marked inhibition of growth in AGS cells, which suggests that patients with poorly differentiated GC may benefit from the blockage of NICD, which potentially serves a role in GC differentiation.

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