Differential Expression of Notch1 Intracellular Domain and P21 Proteins, and Their Clinical Significance in Gastric Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2014 Jan 8

PMID 24396472

Citations 16

Authors

Ding-Hai Luo

Qin Zhou

Sun-Kuan Hu

Yi-Qun Xia

Chao-Chao Xu

Tie-Su Lin

Yu-Ting Pan

Jian-Sheng Wu

Rong Jin

Affiliations

Soon will be listed here.

Abstract

Changes in the expression of the Notch1 intracellular domain (NICD) and p21 proteins have been shown to be closely associated with the development and progression of a number of cancers. The present study aimed to investigate the expression levels of the two proteins in gastric carcinoma and precancerous lesions, and to determine the clinical significance of this. A total of 109 gastric cancer, 57 precancerous gastric lesion, 50 chronic superficial gastritis and 17 normal gastric mucosa patients were recruited for immunohistochemical staining of NICD and p21 protein expression. The protein expression levels in the gastric cancer patient samples were associated with the clinicopathological and survival data. NICD protein levels were upregulated gradually from normal gastric mucosae through chronic superficial gastritis and precancerous gastric lesions to gastric cancer tissues (P<0.01), whereas p21 protein levels were downregulated accordingly (P<0.01). Increased NICD and a loss of p21 expression were closely associated with tumor dedifferentiation, depth of tumor invasion, lymph node metastasis, surface morphology and Lauren classification in gastric cancer. Thus, NICD expression was inversely associated with p21 expression. In addition, the overall survival rate was greater in NICD and P21 patients than in NICD and P21 patients, respectively (P<0.05). The COX regression multivariate analysis revealed that NICD, p21, depth of tumor invasion and lymph node metastasis were all independent prognostic factors for patients with gastric cancer. NICD and p21 proteins are differentially expressed in gastric cancer and the aberrant expression of these proteins is associated with an advanced tumor stage, tumor metastasis and overall patient survival. Future studies are required to further evaluate the two proteins as novel prognostic markers for patients with gastric cancer.

Citing Articles

Gastric Damage and Cancer-Associated Biomarkers in -Infected Children.

George S, Lucero Y, Torres J, Lagomarcino A, ORyan M Front Microbiol. 2020; 11:90.

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Elevated Expression of NOTCH1 Associates with Lymph Node Metastasis of Gastric Cancer and Knock-Down of NOTCH1 Attenuates Tumor Cell Progression.

Huang B, Jin G, Qu C, Ma H, Ding C, Zhang Y Med Sci Monit. 2019; 25:9939-9948.

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Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2.

Morrugares R, Correa-Saez A, Moreno R, Garrido-Rodriguez M, Munoz E, de la Vega L Cell Mol Life Sci. 2019; 77(13):2621-2639.

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The Pattern of Signatures in Gastric Cancer Prognosis.

Machlowska J, Maciejewski R, Sitarz R Int J Mol Sci. 2018; 19(6).

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