Endo and Exo Diels-Alder Adducts: Temperature-Tunable Building Blocks for Selective Chemical Functionalization

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2018 Apr 4

PMID 29613783

Citations 16

Authors

Emre H Discekici

Andre H St Amant

Shay N Nguyen

In-Hwan Lee

Craig J Hawker

Javier Read de Alaniz

Affiliations

Soon will be listed here.

Abstract

The development and application of a novel endo furan-protected maleimide building block is reported. The endo isomer undergoes deprotection at temperatures ∼50 °C below the exo derivative. This enables a simple and powerful approach to quantitatively and selectively introduce functional maleimide groups via temperature modulation.

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