Tunable Orthogonal Reversible Covalent (TORC) Bonds: Dynamic Chemical Control over Molecular Assembly

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2018 Aug 12

PMID 30098086

Citations 29

Authors

James F Reuther

Samuel D Dahlhauser

Eric V Anslyn

Affiliations

Soon will be listed here.

Abstract

Dynamic assembly of macromolecules in biological systems is one of the fundamental processes that facilitates life. Although such assembly most commonly uses noncovalent interactions, a set of dynamic reactions involving reversible covalent bonding is actively being exploited for the design of functional materials, bottom-up assembly, and molecular machines. This Minireview highlights recent implementations and advancements in the area of tunable orthogonal reversible covalent (TORC) bonds for these purposes, and provides an outlook for their expansion, including the development of synthetically encoded polynucleotide mimics.

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