Early Diagnosis of Type 2 Diabetes Based on Multiple Biomarkers and Non-invasive Indices

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2018 Apr 4

PMID 29610560

Citations 5

Authors

Aya Umeno

Toshiki Fukui

Yoshiko Hashimoto

Masatoshi Kataoka

Yoshihisa Hagihara

Hidenori Nagai

Masanori Horie

Mototada Shichiri

Kohzoh Yoshino

Yasukazu Yoshida

Affiliations

Soon will be listed here.

Abstract

We previously reported that type 2 diabetes risk, early impaired glucose tolerance and insulin resistance can be predicted by measuring the fasting levels of certain biomarkers. Here we validated these findings in randomly recruited healthy volunteers ( = 101) based on biomarker expression as well as various non-invasive indices. Weight, body mass index, waist circumference and visceral fat differed between individuals with impaired fasting glucose and/or impaired glucose tolerance, and normal subjects. Fasting plasma levels of glycated hemoglobin, leptin, pro-insulin and retinol binding protein 4 differed between impaired fasting glucose/impaired glucose tolerance and normal subjects group and between newly detected diabetes and normal subjects group. Insulin resistance was correlated with fasting levels of insulin and leptin/adiponectin ( = 0.913); of insulin, retinol binding protein 4 and leptin/adiponectin ( = 0.903); and of insulin, glycated albumin, and leptin/adiponectin ( = 0.913). Type 2 diabetes risk, early impaired glucose tolerance and insulin resistance were predicted with >98% specificity and sensitivity by comparing fasting glucose levels to the estimated Matsuda Index based on fasting levels of insulin, adiponectin and leptin with or without oxidative lineolate metabolites. Non-invasive indices are slightly correlated with glucose tolerance and insulin resistance but do not increase the accuracy of predicting type 2 diabetes risk.

Citing Articles

Significance of Singlet Oxygen Molecule in Pathologies.

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Utility of hemoglobin A1c in detecting risk of type 2 diabetes: comparison of hemoglobin A1c with other biomarkers.

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Comprehensive measurements of hydroxylinoleate and hydroxyarachidonate isomers in blood samples from primary open-angle glaucoma patients and controls.

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