Neural Correlates of Attentional Processing of Threat in Youth with and Without Anxiety Disorders

Overview

Journal J Abnorm Child Psychol

Publisher Springer

Date 2018 Apr 3

PMID 29607460

Citations 17

Authors

Michele Bechor

Michelle L Ramos

Michael J Crowley

Wendy K Silverman

Jeremy W Pettit

Bethany C Reeb-Sutherland

Affiliations

Soon will be listed here.

Abstract

Late-stage attentional processing of threatening stimuli, quantified through event-related potentials (ERPs), differentiates youth with and without anxiety disorders. It is unknown whether early-stage attentional processing of threatening stimuli differentiates these groups. Examining both early and late stage attentional processes in youth may advance knowledge and enhance efforts to identify biomarkers for translational prevention and treatment research. Twenty-one youth with primary DSM-IV-TR anxiety disorders (10 males, ages 8-15 years) and 21 typically developing Controls (15 males, ages 8-16 years) completed a dot probe task while electroencephalography (EEG) was recorded, and ERPs were examined. Youth with anxiety disorders showed significantly larger (more positive) P1 amplitudes for threatening stimuli than for neutral stimuli, and Controls showed the opposite pattern. Youth with anxiety showed larger (more negative) N170 amplitudes compared with Controls. Controls showed significantly larger (more positive) P2 and P3 amplitudes, regardless of stimuli valence, compared with youth with anxiety disorders. ERPs observed during the dot probe task indicate youth with anxiety disorders display distinct neural processing during early stage attentional orienting and processing of faces; this was not the case for Controls. Such results suggest these ERP components may have potential as biomarkers of anxiety disorders in youth.

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References

Bentin S, Allison T, Puce A, Perez E, McCarthy G . Electrophysiological Studies of Face Perception in Humans. J Cogn Neurosci. 2010; 8(6):551-565. PMC: 2927138. DOI: 10.1162/jocn.1996.8.6.551. View

Batty M, Taylor M . Early processing of the six basic facial emotional expressions. Brain Res Cogn Brain Res. 2003; 17(3):613-20. DOI: 10.1016/s0926-6410(03)00174-5. View

Rossignol M, Campanella S, Maurage P, Heeren A, Falbo L, Philippot P . Enhanced perceptual responses during visual processing of facial stimuli in young socially anxious individuals. Neurosci Lett. 2012; 526(1):68-73. DOI: 10.1016/j.neulet.2012.07.045. View

Bar-Haim Y . Research review: Attention bias modification (ABM): a novel treatment for anxiety disorders. J Child Psychol Psychiatry. 2010; 51(8):859-70. DOI: 10.1111/j.1469-7610.2010.02251.x. View

Bar-Haim Y, Lamy D, Pergamin L, Bakermans-Kranenburg M, van IJzendoorn M . Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychol Bull. 2007; 133(1):1-24. DOI: 10.1037/0033-2909.133.1.1. View

Thai N, Taber-Thomas B, Perez-Edgar K . Neural correlates of attention biases, behavioral inhibition, and social anxiety in children: An ERP study. Dev Cogn Neurosci. 2016; 19:200-10. PMC: 4912890. DOI: 10.1016/j.dcn.2016.03.008. View

Falkenstein M, Hoormann J, Hohnsbein J . ERP components in Go/Nogo tasks and their relation to inhibition. Acta Psychol (Amst). 1999; 101(2-3):267-91. DOI: 10.1016/s0001-6918(99)00008-6. View

Wren F, Berg E, Heiden L, Kinnamon C, Ohlson L, Bridge J . Childhood anxiety in a diverse primary care population: parent-child reports, ethnicity and SCARED factor structure. J Am Acad Child Adolesc Psychiatry. 2007; 46(3):332-340. DOI: 10.1097/chi.0b013e31802f1267. View

OToole L, DeCicco J, Berthod S, Dennis T . The N170 to angry faces predicts anxiety in typically developing children over a two-year period. Dev Neuropsychol. 2013; 38(5):352-63. PMC: 3967511. DOI: 10.1080/87565641.2013.802321. View

10.

Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P . Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997; 36(7):980-8. DOI: 10.1097/00004583-199707000-00021. View

11.

Eldar S, Yankelevitch R, Lamy D, Bar-Haim Y . Enhanced neural reactivity and selective attention to threat in anxiety. Biol Psychol. 2010; 85(2):252-7. DOI: 10.1016/j.biopsycho.2010.07.010. View

12.

OToole L, Dennis T . Attention training and the threat bias: an ERP study. Brain Cogn. 2011; 78(1):63-73. PMC: 3233611. DOI: 10.1016/j.bandc.2011.10.007. View

13.

Waters A, Mogg K, Bradley B, Pine D . Attentional bias for emotional faces in children with generalized anxiety disorder. J Am Acad Child Adolesc Psychiatry. 2008; 47(4):435-442. DOI: 10.1097/CHI.0b013e3181642992. View

14.

Lonigan C, Vasey M, Phillips B, Hazen R . Temperament, anxiety, and the processing of threat-relevant stimuli. J Clin Child Adolesc Psychol. 2004; 33(1):8-20. DOI: 10.1207/S15374424JCCP3301_2. View

15.

Roy A, Fudge J, Kelly C, Perry J, Daniele T, Carlisi C . Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder. J Am Acad Child Adolesc Psychiatry. 2013; 52(3):290-299.e2. PMC: 3760686. DOI: 10.1016/j.jaac.2012.12.010. View

16.

Suway J, White L, Vanderwert R, Bar-Haim Y, Pine D, Fox N . Modification of threat-processing in non-anxious individuals: a preliminary behavioral and ERP study. J Behav Ther Exp Psychiatry. 2013; 44(3):285-92. PMC: 3615142. DOI: 10.1016/j.jbtep.2012.11.006. View

17.

MacLeod C, Mathews A, Tata P . Attentional bias in emotional disorders. J Abnorm Psychol. 1986; 95(1):15-20. DOI: 10.1037//0021-843x.95.1.15. View

18.

Birmaher B, Brent D, Chiappetta L, Bridge J, Monga S, Baugher M . Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. J Am Acad Child Adolesc Psychiatry. 1999; 38(10):1230-6. DOI: 10.1097/00004583-199910000-00011. View

19.

Bar-Haim Y, Lamy D, Glickman S . Attentional bias in anxiety: a behavioral and ERP study. Brain Cogn. 2005; 59(1):11-22. DOI: 10.1016/j.bandc.2005.03.005. View

20.

Silverman W, Saavedra L, Pina A . Test-retest reliability of anxiety symptoms and diagnoses with the Anxiety Disorders Interview Schedule for DSM-IV: child and parent versions. J Am Acad Child Adolesc Psychiatry. 2001; 40(8):937-44. DOI: 10.1097/00004583-200108000-00016. View