Greenshell™ Mussels: A Review of Veterinary Trials and Future Research Directions

Overview

Journal Vet Sci

Publisher MDPI

Specialty Veterinary Medicine

Date 2018 Mar 28

PMID 29584640

Citations 5

Authors

Charles T Eason

Serean L Adams

Jonathan Puddick

Donato Romanazzi

Matthew R Miller

Nick King

Sarah Johns

Elizabeth Forbes-Blom

Paul A Hessian

Lisa K Stamp

Michael A Packer

Affiliations

Soon will be listed here.

Abstract

The therapeutic benefits of Greenshell™ mussel (GSM; ) preparations have been studied using test systems, animal models, and human clinical trials focusing mainly on anti-inflammatory and anti-arthritic effects. Activity is thought to be linked to key active ingredients that include omega-3 polyunsaturated fatty acids, a variety of carotenoids and other bioactive compounds. In this paper, we review the studies that have been undertaken in dogs, cats, and horses, and outline new research directions in shellfish breeding and high-value nutrition research programmes targeted at enhancing the efficacy of mussel and algal extracts. The addition of GSM to animal diets has alleviated feline degenerative joint disease and arthritis symptoms, and chronic orthopaedic pain in dogs. In horses, GSM extracts decreased the severity of lameness and joint pain and provided improved joint flexion in limbs with lameness attributed to osteoarthritis. Future research in this area should focus on elucidating the key active ingredients in order to link concentrations of these active ingredients with their pharmacokinetics and therapeutic effects. This would enable consistent and improved efficacy from GSM-based products for the purpose of improved animal health.

Citing Articles

The efficacy of a nutritional supplement containing green-lipped mussel, curcumin and blackcurrant leaf extract in dogs and cats with osteoarthritis.

Corbee R Vet Med Sci. 2022; 8(3):1025-1035.

PMID: 35274496 PMC: 9122405. DOI: 10.1002/vms3.779.

Non-polar lipid from greenshell mussel (Perna canaliculus) inhibits osteoclast differentiation.

Siriarchavatana P, Kruger M, Miller M, Tian H, Wolber F Bone Rep. 2021; 15:101132.

PMID: 34632003 PMC: 8493498. DOI: 10.1016/j.bonr.2021.101132.

Domestication Explains Two-Thirds of Differential-Gene-Expression Variance between Domestic and Wild Animals; The Remaining One-Third Reflects Intraspecific and Interspecific Variation.

Chadaeva I, Ponomarenko P, Kozhemyakina R, Suslov V, Bogomolov A, Klimova N Animals (Basel). 2021; 11(9).

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The Anti-Inflammatory and the Antinociceptive Effects of Mixed Ledeb. and Bunge Extract.

Feng J, Kim H, Sim S, Zuo G, Jung J, Hwang S Plants (Basel). 2021; 10(6).

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Bioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formats.

Miller M, Kruger M, Wynne C, Waaka D, Li W, Frampton C Mar Drugs. 2020; 18(11).

PMID: 33114125 PMC: 7690812. DOI: 10.3390/md18110524.

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